ID   CHH_PENSC               Reviewed;          72 AA.
AC   P59685;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2003, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Crustacean hyperglycemic hormone;
DE            Short=CHH;
OS   Penaeus schmitti (White shrimp) (Litopenaeus schmitti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=122378;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT VAL-72, AND MASS SPECTROMETRY.
RC   TISSUE=Sinus gland;
RX   PubMed=10793213; DOI=10.1016/s0196-9781(00)00155-8;
RA   Huberman A., Aguilar M.B., Navarro-Quiroga I., Ramos L., Fernandez I.,
RA   White F.M., Hunt D.F.;
RT   "A hyperglycemic peptide hormone from the Caribbean shrimp Penaeus
RT   (litopenaeus) schmitti.";
RL   Peptides 21:331-338(2000).
RN   [2]
RP   ERRATUM OF PUBMED:10793213.
RX   PubMed=10876060; DOI=10.1016/s0196-9781(00)00223-0;
RA   Huberman A., Aguilar M.B., Navarro-Quiroga I., Ramos L., Fernandez I.,
RA   White F.M., Hunt D.F., Schabanowitz J.;
RL   Peptides 21:753-753(2000).
CC   -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC       which controls the blood sugar level. Has a secretagogue action over
CC       the amylase released from the midgut gland. May act as a stress hormone
CC       and may be involved in the control of molting and reproduction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=8359.4; Mass_error=0.1; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:10793213};
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P59685; -.
DR   SMR; P59685; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR000346; Hyperglycemic1.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Carbohydrate metabolism; Direct protein sequencing;
KW   Disulfide bond; Glucose metabolism; Hormone; Neuropeptide; Secreted.
FT   CHAIN           1..72
FT                   /note="Crustacean hyperglycemic hormone"
FT                   /id="PRO_0000209858"
FT   MOD_RES         72
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:10793213"
FT   DISULFID        7..43
FT                   /evidence="ECO:0000250"
FT   DISULFID        23..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        26..52
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   72 AA;  8366 MW;  7E646DF8B5EE9A96 CRC64;
     ANFDPSCTGV YDRELLGRLS RLCDDCYNVF REPKVATECR SNCFYNPVFV QCLEYLIPAD
     LHEEYQAHVQ TV