ID   CHH_PROCL               Reviewed;         137 AA.
AC   Q25683; Q9U5F0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2001, sequence version 3.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Crustacean hyperglycemic hormones;
DE   Contains:
DE     RecName: Full=CHH precursor-related peptide;
DE              Short=CPRP;
DE   Contains:
DE     RecName: Full=Crustacean hyperglycemic hormone;
DE              Short=CHH;
DE   Flags: Precursor;
OS   Procambarus clarkii (Red swamp crayfish).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC   Astacoidea; Cambaridae; Procambarus.
OX   NCBI_TaxID=6728;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Yasuda-Kamatani Y., Yasuda A.;
RT   "Crustacean hyperglycemic hormone precursor from Procambarus clarkii.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 56-90.
RA   Kang W.;
RL   Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 64-135, PYROGLUTAMATE FORMATION AT GLN-64, D-AMINO ACID
RP   AT PHE-66, AMIDATION AT VAL-135, AND DISULFIDE BONDS.
RC   TISSUE=Sinus gland;
RX   PubMed=7821776; DOI=10.1006/gcen.1994.1138;
RA   Yasuda A., Yasuda Y., Fujita T., Naya Y.;
RT   "Characterization of crustacean hyperglycemic hormone from the crayfish
RT   (Procambarus clarkii): multiplicity of molecular forms by stereoinversion
RT   and diverse functions.";
RL   Gen. Comp. Endocrinol. 95:387-398(1994).
CC   -!- FUNCTION: Hormone found in the sinus gland of isopods and decapods
CC       which controls the blood sugar level. Has a secretagogue action over
CC       the amylase released from the midgut gland. May act as a stress hormone
CC       and may be involved in the control of molting and reproduction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced by the medulla terminalis X-organ in the
CC       eyestalks and transported to the sinus gland where they are stored and
CC       released.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   EMBL; AB027291; BAA89003.1; -; mRNA.
DR   EMBL; D14610; BAA03462.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q25683; -.
DR   SMR; Q25683; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR000346; Hyperglycemic1.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Carbohydrate metabolism; Cleavage on pair of basic residues;
KW   D-amino acid; Direct protein sequencing; Disulfide bond;
KW   Glucose metabolism; Hormone; Neuropeptide; Pyrrolidone carboxylic acid;
KW   Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         29..61
FT                   /note="CHH precursor-related peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000019073"
FT   PEPTIDE         64..135
FT                   /note="Crustacean hyperglycemic hormone"
FT                   /id="PRO_0000019074"
FT   MOD_RES         64
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:7821776"
FT   MOD_RES         66
FT                   /note="D-phenylalanine; in form CHH-II"
FT                   /evidence="ECO:0000269|PubMed:7821776"
FT   MOD_RES         135
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:7821776"
FT   DISULFID        70..106
FT                   /evidence="ECO:0000269|PubMed:7821776"
FT   DISULFID        86..102
FT                   /evidence="ECO:0000269|PubMed:7821776"
FT   DISULFID        89..115
FT                   /evidence="ECO:0000269|PubMed:7821776"
SQ   SEQUENCE   137 AA;  15264 MW;  7E58C51F9BE2CF57 CRC64;
     MVSFRTMWSL VVVVVVVAAS LGSSGVHGRS VEGSSRMERL LSSGSSSSEP LSFLSQDQSV
     NKRQVFDQAC KGIYDRAIFK KLDRVCEDCY NLYRKPYVAT TCRQNCYANS VFRQCLDDLL
     LIDVVDEYIS GVQTVGK