CHIC1_MOUSE
ID CHIC1_MOUSE Reviewed; 227 AA.
AC Q8CBW7; O08904; Q8K3S5;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Cysteine-rich hydrophobic domain-containing protein 1;
DE AltName: Full=Brain X-linked protein;
GN Name=Chic1; Synonyms=Brx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=9321471; DOI=10.1007/s003359900561;
RA Simmler M.-C., Heard E., Rougeulle C., Cruaud C., Weissenbach J., Avner P.;
RT "Localization and expression analysis of a novel conserved brain expressed
RT transcript, Brx/BRX, lying within the Xic/XIC candidate region.";
RL Mamm. Genome 8:760-766(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=12045143; DOI=10.1101/gr.152902;
RA Chureau C., Prissette M., Bourdet A., Barbe V., Cattolico L., Jones L.,
RA Eggen A., Avner P., Duret L.;
RT "Comparative sequence analysis of the X-inactivation center region in
RT mouse, human and bovine.";
RL Genome Res. 12:894-908(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasmic vesicle
CC {ECO:0000250}. Note=Also present at a Golgi-like vesicular compartment
CC and at scattered vesicles. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed moderately in the brain.
CC {ECO:0000269|PubMed:9321471}.
CC -!- DEVELOPMENTAL STAGE: Detected in the 7, 11, 15, or 19 dpc.
CC {ECO:0000269|PubMed:9321471}.
CC -!- PTM: Palmitoylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CHIC family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-8 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC28706.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA72638.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; Y11896; CAA72638.1; ALT_SEQ; mRNA.
DR EMBL; AJ421479; CAD33951.1; -; Genomic_DNA.
DR EMBL; AK034427; BAC28706.1; ALT_FRAME; mRNA.
DR CCDS; CCDS53165.1; -.
DR RefSeq; NP_033897.1; NM_009767.2.
DR AlphaFoldDB; Q8CBW7; -.
DR SMR; Q8CBW7; -.
DR STRING; 10090.ENSMUSP00000112246; -.
DR iPTMnet; Q8CBW7; -.
DR PhosphoSitePlus; Q8CBW7; -.
DR MaxQB; Q8CBW7; -.
DR PaxDb; Q8CBW7; -.
DR PRIDE; Q8CBW7; -.
DR ProteomicsDB; 281463; -.
DR Antibodypedia; 27995; 21 antibodies from 10 providers.
DR DNASU; 12212; -.
DR Ensembl; ENSMUST00000116547; ENSMUSP00000112246; ENSMUSG00000031327.
DR GeneID; 12212; -.
DR KEGG; mmu:12212; -.
DR UCSC; uc009tzl.2; mouse.
DR CTD; 53344; -.
DR MGI; MGI:1344694; Chic1.
DR VEuPathDB; HostDB:ENSMUSG00000031327; -.
DR eggNOG; KOG4101; Eukaryota.
DR GeneTree; ENSGT00390000003601; -.
DR HOGENOM; CLU_100628_0_0_1; -.
DR InParanoid; Q8CBW7; -.
DR OMA; HITVXVA; -.
DR OrthoDB; 1449345at2759; -.
DR PhylomeDB; Q8CBW7; -.
DR TreeFam; TF314908; -.
DR BioGRID-ORCS; 12212; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Chic1; mouse.
DR PRO; PR:Q8CBW7; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8CBW7; protein.
DR Bgee; ENSMUSG00000031327; Expressed in islet of Langerhans and 200 other tissues.
DR ExpressionAtlas; Q8CBW7; baseline and differential.
DR Genevisible; Q8CBW7; MM.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR039735; CHIC1/2.
DR InterPro; IPR019383; Golgin_A_7/ERF4.
DR PANTHER; PTHR13005; PTHR13005; 1.
DR Pfam; PF10256; Erf4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Cytoplasmic vesicle; Lipoprotein; Membrane;
KW Palmitate; Reference proteome.
FT CHAIN 1..227
FT /note="Cysteine-rich hydrophobic domain-containing protein
FT 1"
FT /id="PRO_0000189555"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 46..73
FT /evidence="ECO:0000255"
FT COMPBIAS 24..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..72
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 193
FT /note="A -> V (in Ref. 1; CAA72638)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 227 AA; 25791 MW; 10C866CE9126AD97 CRC64;
MSILLPNMAE FDTISELEEE EEAATSSSSP SSSPSSSSSS SVSGPDEDEE DEEEEEEEDE
EEEDEEEEEE EVPPPPRVVS EEHLRRYAPD PVLVRGAGHI TVFGLSNKFD TEFPSVLTGK
VAPEEFKTSI GRVNSCLKKA LPVNVKWLLC GCLCCCCTLG CSLWPVICLN KRTRRSIQKL
LEWENNRLYH KLALHWKLTK RKCETSNMME YVILIEFLPK YPIFRPD
