CHIC2_MOUSE
ID CHIC2_MOUSE Reviewed; 165 AA.
AC Q9D9G3; Q0VG23; Q3T9U2; Q80ZT7;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Cysteine-rich hydrophobic domain-containing protein 2;
GN Name=Chic2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Associated
CC and found in vesicular structures of Golgi complex. {ECO:0000250}.
CC -!- PTM: Palmitoylation in the CHIC motif is required for membrane
CC association. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CHIC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK006962; BAB24808.1; -; mRNA.
DR EMBL; AK172289; BAE42928.1; -; mRNA.
DR EMBL; BC048435; AAH48435.1; -; mRNA.
DR EMBL; BC116971; AAI16972.1; -; mRNA.
DR EMBL; BC116973; AAI16974.1; -; mRNA.
DR CCDS; CCDS19349.1; -.
DR RefSeq; NP_083126.1; NM_028850.5.
DR AlphaFoldDB; Q9D9G3; -.
DR SMR; Q9D9G3; -.
DR STRING; 10090.ENSMUSP00000074903; -.
DR iPTMnet; Q9D9G3; -.
DR PhosphoSitePlus; Q9D9G3; -.
DR MaxQB; Q9D9G3; -.
DR PaxDb; Q9D9G3; -.
DR PRIDE; Q9D9G3; -.
DR ProteomicsDB; 283827; -.
DR Antibodypedia; 12265; 144 antibodies from 22 providers.
DR DNASU; 74277; -.
DR Ensembl; ENSMUST00000075452; ENSMUSP00000074903; ENSMUSG00000029229.
DR GeneID; 74277; -.
DR KEGG; mmu:74277; -.
DR UCSC; uc008xtw.1; mouse.
DR CTD; 26511; -.
DR MGI; MGI:1921527; Chic2.
DR VEuPathDB; HostDB:ENSMUSG00000029229; -.
DR eggNOG; KOG4101; Eukaryota.
DR GeneTree; ENSGT00390000003601; -.
DR HOGENOM; CLU_100628_1_0_1; -.
DR InParanoid; Q9D9G3; -.
DR OMA; MEKLLEW; -.
DR OrthoDB; 1449345at2759; -.
DR PhylomeDB; Q9D9G3; -.
DR TreeFam; TF314908; -.
DR BioGRID-ORCS; 74277; 12 hits in 76 CRISPR screens.
DR ChiTaRS; Chic2; mouse.
DR PRO; PR:Q9D9G3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9D9G3; protein.
DR Bgee; ENSMUSG00000029229; Expressed in gastrula and 248 other tissues.
DR Genevisible; Q9D9G3; MM.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0005798; C:Golgi-associated vesicle; IDA:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; TAS:MGI.
DR InterPro; IPR039735; CHIC1/2.
DR InterPro; IPR019383; Golgin_A_7/ERF4.
DR PANTHER; PTHR13005; PTHR13005; 1.
DR Pfam; PF10256; Erf4; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Golgi apparatus; Lipoprotein; Membrane; Palmitate;
KW Reference proteome.
FT CHAIN 1..165
FT /note="Cysteine-rich hydrophobic domain-containing protein
FT 2"
FT /id="PRO_0000189557"
FT COILED 1..26
FT /evidence="ECO:0000255"
FT MOTIF 88..106
FT /note="CHIC motif (Cys-rich)"
FT CONFLICT 1
FT /note="M -> AAGGSGCCCGCRSCGGDGGGAGAGGGAG (in Ref. 2;
FT AAH48435)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 165 AA; 19282 MW; DC2A20DD14ADADD7 CRC64;
MADFDEIYEE EEDEERALEE QLLKYSPDPV VVRGSGHVTV FGLSNKFESE FPSSLTGKVA
PEEFKASINR VNSCLRKNLP VNVRWLLCGC LCCCCTLGCS MWPVICLSKR TRRSIEKLLE
WENNRLYHKL CLHWRLSKRK CETNNMMEYV ILIEFLPKTP IFRPD
