ID   CHID1_BOVIN             Reviewed;         393 AA.
AC   Q5EAB4; Q17QB6;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Chitinase domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=CHID1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Saccharide- and LPS-binding protein with possible roles in
CC       pathogen sensing and endotoxin neutralization. Ligand-binding
CC       specificity relates to the length of the oligosaccharides, with
CC       preference for chitotetraose (in vitro) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STAB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Lysosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. {ECO:0000305}.
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DR   EMBL; BT020630; AAX08647.1; -; mRNA.
DR   EMBL; BT020655; AAX08672.1; -; mRNA.
DR   EMBL; BT020789; AAX08806.1; -; mRNA.
DR   EMBL; BT020873; AAX08890.1; -; mRNA.
DR   EMBL; BT021168; AAX31350.1; -; mRNA.
DR   EMBL; BT021170; AAX31352.1; -; mRNA.
DR   EMBL; BT021178; AAX31360.1; -; mRNA.
DR   EMBL; BC118449; AAI18450.1; -; mRNA.
DR   RefSeq; NP_001015515.1; NM_001015515.1.
DR   AlphaFoldDB; Q5EAB4; -.
DR   SMR; Q5EAB4; -.
DR   PRIDE; Q5EAB4; -.
DR   Ensembl; ENSBTAT00000054178; ENSBTAP00000050339; ENSBTAG00000009899.
DR   Ensembl; ENSBTAT00000074326; ENSBTAP00000060623; ENSBTAG00000009899.
DR   GeneID; 504781; -.
DR   KEGG; bta:504781; -.
DR   CTD; 66005; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009899; -.
DR   VGNC; VGNC:27294; CHID1.
DR   GeneTree; ENSGT00390000012069; -.
DR   HOGENOM; CLU_035132_2_0_1; -.
DR   InParanoid; Q5EAB4; -.
DR   OMA; YSINERI; -.
DR   OrthoDB; 1067925at2759; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000009899; Expressed in saliva-secreting gland and 112 other tissues.
DR   ExpressionAtlas; Q5EAB4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR   GO; GO:0070492; F:oligosaccharide binding; IBA:GO_Central.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.10; -; 1.
DR   InterPro; IPR011583; Chitinase_II.
DR   InterPro; IPR029070; Chitinase_insertion_sf.
DR   InterPro; IPR001223; Glyco_hydro18_cat.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   Pfam; PF00704; Glyco_hydro_18; 1.
DR   SMART; SM00636; Glyco_18; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS51910; GH18_2; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Innate immunity; Lysosome; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..393
FT                   /note="Chitinase domain-containing protein 1"
FT                   /id="PRO_0000280607"
FT   DOMAIN          79..393
FT                   /note="GH18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01258"
FT   CONFLICT        190
FT                   /note="V -> M (in Ref. 2; AAI18450)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   393 AA;  44562 MW;  D3AE54A6660B64AE CRC64;
     MRVLLGTLWL TLACSSVHAT LSKSDAKKAA SKTLQEKTQV SGKPAQERGL VVTDLRAEDV
     VLEHRSYCSA KAHRKHFAGD VLGYITPWNR HGYDVAKIFG GKFTHVAPVW LQLRRHGREM
     FEVTGLDDVD QGWLRAVRKQ AKGLRIVPRL RFEDWTYEDF DSVLDNEDEI EELSRTVVQV
     AKSQHFDGLV VEVWNQLLVQ KHAGLIHLLT HMAEALHQAR LLVFLVIPPA VAPGTNKLGM
     FTNTEFEQLA PVLDGFSLMT YDYSTAQPAG PNAPLPWVRA CVQVLDPKSK WRSKILLGLN
     FYGMDYSASK DAREPIIGAR YIQTLKDHRP QVVWDSQAAE HFFEYKKSRG GRHVVFYPTL
     KSLQERLELA QELGVGLSIW ELGQGLDYFY DLL