ID   CHID1_PONAB             Reviewed;         393 AA.
AC   Q5RFF6;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Chitinase domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=CHID1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Saccharide- and LPS-binding protein with possible roles in
CC       pathogen sensing and endotoxin neutralization. Ligand-binding
CC       specificity relates to the length of the oligosaccharides, with
CC       preference for chitotetraose (in vitro) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STAB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Lysosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. {ECO:0000305}.
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DR   EMBL; CR857202; CAH89501.1; -; mRNA.
DR   RefSeq; NP_001127157.1; NM_001133685.1.
DR   AlphaFoldDB; Q5RFF6; -.
DR   SMR; Q5RFF6; -.
DR   STRING; 9601.ENSPPYP00000003363; -.
DR   PRIDE; Q5RFF6; -.
DR   Ensembl; ENSPPYT00000052778; ENSPPYP00000031728; ENSPPYG00000002892.
DR   GeneID; 100174208; -.
DR   KEGG; pon:100174208; -.
DR   CTD; 66005; -.
DR   eggNOG; KOG2091; Eukaryota.
DR   GeneTree; ENSGT00390000012069; -.
DR   HOGENOM; CLU_035132_2_0_1; -.
DR   InParanoid; Q5RFF6; -.
DR   OrthoDB; 1067925at2759; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.10; -; 1.
DR   InterPro; IPR011583; Chitinase_II.
DR   InterPro; IPR029070; Chitinase_insertion_sf.
DR   InterPro; IPR001223; Glyco_hydro18_cat.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   Pfam; PF00704; Glyco_hydro_18; 1.
DR   SMART; SM00636; Glyco_18; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS51910; GH18_2; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Innate immunity; Lysosome; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..393
FT                   /note="Chitinase domain-containing protein 1"
FT                   /id="PRO_0000280610"
FT   DOMAIN          79..393
FT                   /note="GH18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01258"
SQ   SEQUENCE   393 AA;  44925 MW;  8EF3CC99C33A3EC1 CRC64;
     MRTLFNLLWL ALACSPVHAT LSKSDAKKAA SKTLLEKSQF SDKPVQERGL VVTDLKAESV
     VLEHRSYCSA KARDRHFAGD VLGYVTPWNS HGYDVTKVFG SKFTQISPVW LQLKRRGREM
     FEVTGLHDVD QGWMRAVRKH AKGLHIVPRL LFEDWTYDDF RNVLDSEDEI EELSKTVVQV
     AKNQHFDGFV VEVWNQLLSQ KRVGLIHMLT HLAEALHQAR LLALLVIPPA ITPGTDQLGM
     FTHKEFEQLA PVLDGFSLMT YDYSTAHQPG PNAPLSWVRA CVQVLDPKSK WRSKILLGLN
     FYGMDYATSK DAREPVVGAR YIQTLKDHRP RMVWDSQASE HFFEYKKSRS GRHVVFYPTL
     KSLQVRLELA RELGVGVSIW ELGQGLDYFY DLL