ID   CHID1_RAT               Reviewed;         393 AA.
AC   A0JPQ9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Chitinase domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=Chid1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Saccharide- and LPS-binding protein with possible roles in
CC       pathogen sensing and endotoxin neutralization. Ligand-binding
CC       specificity relates to the length of the oligosaccharides, with
CC       preference for chitotetraose (in vitro) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STAB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Lysosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI27547.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC127546; AAI27547.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001041319.2; NM_001047854.2.
DR   RefSeq; XP_008758256.1; XM_008760034.2.
DR   RefSeq; XP_008758257.1; XM_008760035.2.
DR   RefSeq; XP_017459701.1; XM_017604212.1.
DR   RefSeq; XP_017459702.1; XM_017604213.1.
DR   AlphaFoldDB; A0JPQ9; -.
DR   SMR; A0JPQ9; -.
DR   STRING; 10116.ENSRNOP00000026390; -.
DR   jPOST; A0JPQ9; -.
DR   PaxDb; A0JPQ9; -.
DR   PeptideAtlas; A0JPQ9; -.
DR   GeneID; 293628; -.
DR   KEGG; rno:293628; -.
DR   UCSC; RGD:1308955; rat.
DR   CTD; 66005; -.
DR   RGD; 1308955; Chid1.
DR   eggNOG; KOG2091; Eukaryota.
DR   InParanoid; A0JPQ9; -.
DR   OrthoDB; 1067925at2759; -.
DR   Reactome; R-RNO-114608; Platelet degranulation.
DR   PRO; PR:A0JPQ9; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0005770; C:late endosome; ISO:RGD.
DR   GO; GO:0005764; C:lysosome; ISO:RGD.
DR   GO; GO:0005802; C:trans-Golgi network; ISO:RGD.
DR   GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR   GO; GO:0070492; F:oligosaccharide binding; ISO:RGD.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; ISO:RGD.
DR   Gene3D; 3.10.50.10; -; 1.
DR   InterPro; IPR011583; Chitinase_II.
DR   InterPro; IPR029070; Chitinase_insertion_sf.
DR   InterPro; IPR001223; Glyco_hydro18_cat.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   Pfam; PF00704; Glyco_hydro_18; 1.
DR   SMART; SM00636; Glyco_18; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS51910; GH18_2; 1.
PE   2: Evidence at transcript level;
KW   Immunity; Innate immunity; Lysosome; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..393
FT                   /note="Chitinase domain-containing protein 1"
FT                   /id="PRO_0000280611"
FT   DOMAIN          79..393
FT                   /note="GH18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01258"
SQ   SEQUENCE   393 AA;  44875 MW;  FB53198F7A9E499F CRC64;
     MWPLLHVLWL ALVCGSVHTT LSKSDAKKAA SKTLLEKTQF SDKPVQDRGL VVTDIKAEDV
     VLEHRSYCSA RARERNFAGE VLGYVTPWNS HGYDVAKVFG SKFTQISPVW LQLKRRGREM
     FEITGLHDVD QGWMRAVKKH AKGVRIVPRL LFEDWTYDDF RSVLDSEDEI EELSKTVVQV
     AKNQHFDGFV VEVWSQLLSQ KHVGLIHMLT HLAEALHQAR LLVILVIPPA VTPGTDQLGM
     FTHKEFEQLA PILDGFSLMT YDYSTSQQPG PNAPLSWIRA CVQVLDPKSQ WRSKILLGLN
     FYGMDYAASK DAREPVIGAR YIQTLKDHRP RVVWDSQAAE HFFEYKKNRG GRHVVFYPTL
     KSLQVRLELA RELGVGVSIW ELGQGLDYFY DLL