ID   CHIPS_STAA3             Reviewed;         149 AA.
AC   Q2FFF7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Chemotaxis inhibitory protein;
DE   AltName: Full=CHIPS;
DE   Flags: Precursor;
GN   Name=chp; Synonyms=chs; OrderedLocusNames=SAUSA300_1920;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Involved in countering the first line of host defense
CC       mechanisms. Specifically inhibits the response of human neutrophils and
CC       monocytes to complement anaphylatoxin C5a and formylated peptides, like
CC       N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding
CC       directly to the C5a receptor (C5aR) and formylated peptide receptor
CC       (FPR), thereby blocking the C5a- and fMLP-induced calcium responses.
CC       Prevents phagocytosis of the bacterium (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHIPS/FLIPr family. {ECO:0000305}.
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DR   EMBL; CP000255; ABD22075.1; -; Genomic_DNA.
DR   RefSeq; WP_000727649.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FFF7; -.
DR   BMRB; Q2FFF7; -.
DR   SMR; Q2FFF7; -.
DR   PRIDE; Q2FFF7; -.
DR   EnsemblBacteria; ABD22075; ABD22075; SAUSA300_1920.
DR   KEGG; saa:SAUSA300_1920; -.
DR   HOGENOM; CLU_1748521_0_0_9; -.
DR   PRO; PR:Q2FFF7; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.20.390; -; 1.
DR   InterPro; IPR020986; CHIPS.
DR   InterPro; IPR038529; FLIPR/CHIP_sf.
DR   InterPro; IPR023253; FLIPR/CHIPS.
DR   Pfam; PF11434; CHIPS; 1.
DR   PRINTS; PR02036; CHEMOTAXISIP.
DR   PRINTS; PR02035; FLIPRCHIPS.
PE   3: Inferred from homology;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..149
FT                   /note="Chemotaxis inhibitory protein"
FT                   /id="PRO_0000319609"
FT   REGION          29..34
FT                   /note="FPR-blocking activity"
FT                   /evidence="ECO:0000250"
FT   REGION          59..149
FT                   /note="C5aR-blocking activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   149 AA;  17058 MW;  6F5CC73C5BDB36AC CRC64;
     MKKKLATTVL ALSFLTAGIS THHHSAKAFT FEPFPTNEEI ESNKKMLEKE KAYKESFKNS
     GLPTTLGKLD ERLRNYLKKG TKNSAQFEKM VILTENKGYY TVYLNTPLAE DRKNVELLGK
     MYKTYFFKKG ESKSSYVING PGKTNEYAY