ID   CHIP_SALTY              Reviewed;         468 AA.
AC   Q7CQY4;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Chitoporin;
DE   Flags: Precursor;
GN   Name=chiP; OrderedLocusNames=STM0687;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION,
RP   INDUCTION, AND GENE NAME.
RC   STRAIN=LT2 / MA3409;
RX   PubMed=19638370; DOI=10.1101/gad.541609;
RA   Figueroa-Bossi N., Valentini M., Malleret L., Fiorini F., Bossi L.;
RT   "Caught at its own game: regulatory small RNA inactivated by an inducible
RT   transcript mimicking its target.";
RL   Genes Dev. 23:2004-2015(2009).
CC   -!- FUNCTION: Involved in the uptake of chitosugars.
CC       {ECO:0000269|PubMed:19638370}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000269|PubMed:19638370}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:19638370}.
CC   -!- INDUCTION: In the absence of chitobiose, expression of chiPQ is
CC       silenced by the ChiX small regulatory RNA (sRNA), which sequesters the
CC       ribosome binding site of the chiPQ mRNA by an antisense mechanism. In
CC       the presence of chitosugars, the chbBCARFG chitobiose operon is induced
CC       and acts as an RNA trap to degrade the constitutively expressed ChiX,
CC       leading to the translation of chiPQ. Chitobiose and chitotriose also
CC       induce chiP mRNA synthesis. {ECO:0000269|PubMed:19638370}.
CC   -!- SIMILARITY: Belongs to the outer membrane porin (Opr) (TC 1.B.25)
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE006468; AAL19631.1; -; Genomic_DNA.
DR   RefSeq; NP_459672.1; NC_003197.2.
DR   RefSeq; WP_001258803.1; NC_003197.2.
DR   AlphaFoldDB; Q7CQY4; -.
DR   SMR; Q7CQY4; -.
DR   STRING; 99287.STM0687; -.
DR   PaxDb; Q7CQY4; -.
DR   EnsemblBacteria; AAL19631; AAL19631; STM0687.
DR   GeneID; 1252207; -.
DR   KEGG; stm:STM0687; -.
DR   PATRIC; fig|99287.12.peg.718; -.
DR   HOGENOM; CLU_045968_0_0_6; -.
DR   OMA; TWVKAEG; -.
DR   PhylomeDB; Q7CQY4; -.
DR   BioCyc; SENT99287:STM0687-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0015772; P:oligosaccharide transport; IBA:GO_Central.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR005318; OM_porin_bac.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   PANTHER; PTHR34596; PTHR34596; 1.
DR   Pfam; PF03573; OprD; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Ion transport; Membrane; Polysaccharide transport;
KW   Porin; Reference proteome; Signal; Sugar transport; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..468
FT                   /note="Chitoporin"
FT                   /id="PRO_0000417586"
SQ   SEQUENCE   468 AA;  52664 MW;  4FB85F27D9A6A8BC CRC64;
     MRTFSGKRST LALAIAGITA MSGWIVVPQA QASGFFDDST LTGGIYYWQR ERDRKDVTDG
     DKYKTNLSHA TWNANLDFQS GYAADMFGLD IAAFTAIEMA ENGDSGHPNE IAFSKKNKGY
     DEDYSGDKSG ISLYKAAAKF KYGPVWARAG YIQPTGQTLL APHWSFMPGT YQGAEAGASF
     DYGDAGALSF SYMWTNEYKA PWHTEMDKFY QADKKTNVDY LHSIGAKYDF KNDLVLEAAF
     GQSEGYVDQY FAKASYKFDL GGNPFTTSYQ FYGARDKVDD RSVNDIYDGT AWLQALTFGY
     KVAEVVDLRL EGTWVKADGQ QGYFLQRMTP TYASSNGRLD IWWDNRSDFN ANGEKAVFFG
     AMYDLKNWNL PGWAVGASYV YAWDAKPATW QSNPDAYYDK NRTIEESSYS LDAVYTLQEG
     RAKGTMFKLH FTEYDNHSNI PSWGGGYGNI FQDERDVKFI VIAPFTIF