ID   CHLER_MYCTO             Reviewed;         261 AA.
AC   P9WMD2; L0T6E2; P67434; Q11023;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=HTH-type transcriptional repressor MT1396 {ECO:0000250|UniProtKB:P9WMD3};
GN   OrderedLocusNames=MT1396;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Negatively regulates the expression of the efflux pump MT0201
CC       upon chloramphenicol exposure. Acts by binding to the MT0201 promoter
CC       region. {ECO:0000250|UniProtKB:P9WMD3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P9WMD3}.
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DR   EMBL; AE000516; AAK45659.1; -; Genomic_DNA.
DR   PIR; H70740; H70740.
DR   RefSeq; WP_003898836.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMD2; -.
DR   SMR; P9WMD2; -.
DR   EnsemblBacteria; AAK45659; AAK45659; MT1396.
DR   GeneID; 45425332; -.
DR   KEGG; mtc:MT1396; -.
DR   PATRIC; fig|83331.31.peg.1503; -.
DR   HOGENOM; CLU_069543_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR004111; Repressor_TetR_C.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF02909; TetR_C_1; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..261
FT                   /note="HTH-type transcriptional repressor MT1396"
FT                   /id="PRO_0000427324"
FT   DOMAIN          15..75
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        38..57
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   REGION          234..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  28253 MW;  12B447D94D8B03AC CRC64;
     MQTTPGKRQR RQRGSINPED IISGAFELAQ QVSIDNLSMP LLGKHLGVGV TSIYWYFRKK
     DDLLNAMTDR ALSKYVFATP YIEAGDWRET LRNHARSMRK TFADNPVLCD LILIRAALSP
     KTARLGAQEM EKAIANLVTA GLSLEDAFDI YSAVSVHVRG SVVLDRLSRK SQSAGSGPSA
     IEHPVAIDPA TTPLLAHATG RGHRIGAPDE TNFEYGLECI LDHAGRLIEQ SSKAAGEVAV
     RRPTATADAP TPGARAKAVA R