ID   CHLER_MYCTU             Reviewed;         261 AA.
AC   P9WMD3; L0T6E2; P67434; Q11023;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=HTH-type transcriptional repressor Rv1353c {ECO:0000305};
GN   OrderedLocusNames=Rv1353c; ORFNames=MTCY02B10.17c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, DNA-BINDING, AND INDUCTION.
RX   PubMed=31054279; DOI=10.1016/j.abb.2019.04.010;
RA   Li X., Li P., Ruan C., Xie L.X., Gu Y., Li J., Yi Q., Lv X., Xie J.;
RT   "Mycobacterium tuberculosis Rv0191 is an efflux pump of major facilitator
RT   superfamily transporter regulated by Rv1353c.";
RL   Arch. Biochem. Biophys. 667:59-66(2019).
CC   -!- FUNCTION: Negatively regulates the expression of the efflux pump Rv0191
CC       upon chloramphenicol exposure. Acts by binding to the Rv0191 promoter
CC       region. {ECO:0000269|PubMed:31054279}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Autoregulated. {ECO:0000269|PubMed:31054279}.
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DR   EMBL; AL123456; CCP44111.1; -; Genomic_DNA.
DR   PIR; H70740; H70740.
DR   RefSeq; NP_215869.1; NC_000962.3.
DR   RefSeq; WP_003898836.1; NZ_NVQJ01000031.1.
DR   AlphaFoldDB; P9WMD3; -.
DR   SMR; P9WMD3; -.
DR   STRING; 83332.Rv1353c; -.
DR   PaxDb; P9WMD3; -.
DR   DNASU; 886827; -.
DR   GeneID; 45425332; -.
DR   GeneID; 886827; -.
DR   KEGG; mtu:Rv1353c; -.
DR   TubercuList; Rv1353c; -.
DR   eggNOG; COG1309; Bacteria.
DR   OMA; MGNPILC; -.
DR   PhylomeDB; P9WMD3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR004111; Repressor_TetR_C.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF02909; TetR_C_1; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..261
FT                   /note="HTH-type transcriptional repressor Rv1353c"
FT                   /id="PRO_0000070662"
FT   DOMAIN          15..75
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        38..57
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   REGION          234..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  28253 MW;  12B447D94D8B03AC CRC64;
     MQTTPGKRQR RQRGSINPED IISGAFELAQ QVSIDNLSMP LLGKHLGVGV TSIYWYFRKK
     DDLLNAMTDR ALSKYVFATP YIEAGDWRET LRNHARSMRK TFADNPVLCD LILIRAALSP
     KTARLGAQEM EKAIANLVTA GLSLEDAFDI YSAVSVHVRG SVVLDRLSRK SQSAGSGPSA
     IEHPVAIDPA TTPLLAHATG RGHRIGAPDE TNFEYGLECI LDHAGRLIEQ SSKAAGEVAV
     RRPTATADAP TPGARAKAVA R