ID   CHLY_CARPA              Reviewed;          25 AA.
AC   P81241;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Bifunctional chitinase/lysozyme;
DE   Includes:
DE     RecName: Full=Chitinase;
DE              EC=3.2.1.14;
DE   Includes:
DE     RecName: Full=Lysozyme;
DE              EC=3.2.1.17;
DE   Flags: Fragments;
OS   Carica papaya (Papaya).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Caricaceae; Carica.
OX   NCBI_TaxID=3649;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-22.
RC   TISSUE=Latex;
RX   PubMed=10594185; DOI=10.1007/pl00000075;
RA   Subroto T., Sufiati S., Beintema J.J.;
RT   "Papaya (Carica papaya) lysozyme is a member of the family 19 (basic, class
RT   II) chitinases.";
RL   J. Mol. Evol. 49:819-821(1999).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-5 AND 23-25.
RC   TISSUE=Latex;
RX   PubMed=5773045; DOI=10.1016/s0021-9258(18)91775-8;
RA   Howard J.B., Glazer A.N.;
RT   "Papaya lysozyme. Terminal sequences and enzymatic properties.";
RL   J. Biol. Chem. 244:1399-1409(1969).
CC   -!- FUNCTION: Bifunctional enzyme with lysozyme/chitinase activity.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide
CC         (1->4)-beta-linkages in chitin and chitodextrins.; EC=3.2.1.14;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC         acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC         between N-acetyl-D-glucosamine residues in chitodextrins.;
CC         EC=3.2.1.17;
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 19 family. Chitinase
CC       class I subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P81241; -.
DR   Allergome; 1272; Cari p Chitinase.
DR   CAZy; GH19; Glycoside Hydrolase Family 19.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004568; F:chitinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003796; F:lysozyme activity; IEA:UniProtKB-EC.
DR   GO; GO:0006032; P:chitin catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Chitin degradation; Direct protein sequencing;
KW   Glycosidase; Hydrolase; Multifunctional enzyme; Polysaccharide degradation;
KW   Secreted.
FT   CHAIN           1..>25
FT                   /note="Bifunctional chitinase/lysozyme"
FT                   /id="PRO_0000124810"
FT   CONFLICT        3
FT                   /note="E -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_CONS        22..23
FT                   /evidence="ECO:0000305"
FT   NON_TER         25
SQ   SEQUENCE   25 AA;  2877 MW;  33BA3F018F33ACD6 CRC64;
     GIEKIISRSM FDQMLKHRNN PASFG