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CHM1A_ARATH
ID   CHM1A_ARATH             Reviewed;         203 AA.
AC   Q8LE58; Q9FZ60;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=ESCRT-related protein CHMP1A {ECO:0000305};
DE   AltName: Full=Protein CHARGED MULTIVESICULAR BODY PROTEIN 1A {ECO:0000303|PubMed:19304934};
DE   AltName: Full=Protein CHROMATIN MODIFYING PROTEIN 1A {ECO:0000303|PubMed:19304934};
DE   AltName: Full=Vacuolar protein-sorting-associated protein 46.1 {ECO:0000305};
GN   Name=CHMP1A {ECO:0000303|PubMed:19304934};
GN   Synonyms=VPS46.1 {ECO:0000312|EMBL:AEE29628.1};
GN   OrderedLocusNames=At1g17730 {ECO:0000312|Araport:AT1G17730};
GN   ORFNames=F11A6.7 {ECO:0000312|EMBL:AAF99815.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION, INTERACTION WITH SKD1/VPS4 AND LIP5, AND DISRUPTION PHENOTYPE.
RX   PubMed=19304934; DOI=10.1105/tpc.108.064865;
RA   Spitzer C., Reyes F.C., Buono R., Sliwinski M.K., Haas T.J., Otegui M.S.;
RT   "The ESCRT-related CHMP1A and B proteins mediate multivesicular body
RT   sorting of auxin carriers in Arabidopsis and are required for plant
RT   development.";
RL   Plant Cell 21:749-766(2009).
RN   [6]
RP   INTERACTION WITH CHMP1B; SKD1/VPS4 AND LIP5.
RC   STRAIN=cv. Columbia;
RX   PubMed=20663085; DOI=10.1111/j.1365-313x.2010.04310.x;
RA   Shahriari M., Keshavaiah C., Scheuring D., Sabovljevic A., Pimpl P.,
RA   Haeusler R.E., Huelskamp M., Schellmann S.;
RT   "The AAA-type ATPase AtSKD1 contributes to vacuolar maintenance of
RT   Arabidopsis thaliana.";
RL   Plant J. 64:71-85(2010).
RN   [7]
RP   INTERACTION WITH VPS2.2.
RX   PubMed=22010978; DOI=10.1021/pr200845n;
RA   Ibl V., Csaszar E., Schlager N., Neubert S., Spitzer C., Hauser M.T.;
RT   "Interactome of the plant-specific ESCRT-III component AtVPS2.2 in
RT   Arabidopsis thaliana.";
RL   J. Proteome Res. 11:397-411(2012).
RN   [8]
RP   FUNCTION.
RX   PubMed=25649438; DOI=10.1105/tpc.114.135939;
RA   Spitzer C., Li F., Buono R., Roschzttardtz H., Chung T., Zhang M.,
RA   Osteryoung K.W., Vierstra R.D., Otegui M.S.;
RT   "The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the
RT   autophagic turnover of plastids in Arabidopsis.";
RL   Plant Cell 27:391-402(2015).
CC   -!- FUNCTION: Involved in ESCRT-dependent multivesicular body (MVB)
CC       formation and sorting of endosomal cargo proteins into MVBs. Mediates
CC       the MVB sorting of the auxin carriers PIN1, PIN2 and AUX1. Required for
CC       embryonic axis establishment and seedling growth (PubMed:19304934).
CC       Required for autophagic degradation of plastid proteins. Promotes the
CC       efficient sequestration of cargo from plastids into autophagosomes.
CC       Mediates the efficient delivery of autophagic plastid bodies to the
CC       vacuole, but not into the cytoplasm (PubMed:25649438).
CC       {ECO:0000269|PubMed:19304934, ECO:0000269|PubMed:25649438}.
CC   -!- SUBUNIT: Interacts with SKD1/VPS4 and LIP5 (PubMed:19304934,
CC       PubMed:20663085). Interacts with CHMP1B (PubMed:20663085). Interacts
CC       with VPS2.2 (PubMed:22010978). {ECO:0000269|PubMed:19304934,
CC       ECO:0000269|PubMed:20663085, ECO:0000269|PubMed:22010978}.
CC   -!- INTERACTION:
CC       Q8LE58; Q0WTY4: VPS2.2; NbExp=4; IntAct=EBI-6391458, EBI-3865323;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9HD42}.
CC       Endosome membrane {ECO:0000250|UniProtKB:Q9HD42}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:Q9HD42}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions, but double mutants chmp1a and chmp1b show embryo
CC       development defect. {ECO:0000269|PubMed:19304934}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF99815.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC034257; AAF99815.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE29628.1; -; Genomic_DNA.
DR   EMBL; AK118350; BAC42964.1; -; mRNA.
DR   EMBL; AY085606; AAM62827.1; -; mRNA.
DR   PIR; C86312; C86312.
DR   RefSeq; NP_173215.1; NM_101635.5.
DR   AlphaFoldDB; Q8LE58; -.
DR   SMR; Q8LE58; -.
DR   IntAct; Q8LE58; 1.
DR   STRING; 3702.AT1G17730.1; -.
DR   TCDB; 3.A.31.1.2; the endosomal sorting complexes required for transport iii (escrt-iii) family.
DR   iPTMnet; Q8LE58; -.
DR   PaxDb; Q8LE58; -.
DR   PRIDE; Q8LE58; -.
DR   ProteomicsDB; 241027; -.
DR   EnsemblPlants; AT1G17730.1; AT1G17730.1; AT1G17730.
DR   GeneID; 838349; -.
DR   Gramene; AT1G17730.1; AT1G17730.1; AT1G17730.
DR   KEGG; ath:AT1G17730; -.
DR   Araport; AT1G17730; -.
DR   TAIR; locus:2007883; AT1G17730.
DR   eggNOG; KOG3232; Eukaryota.
DR   HOGENOM; CLU_080826_0_1_1; -.
DR   InParanoid; Q8LE58; -.
DR   OMA; MMIPLIQ; -.
DR   OrthoDB; 1441797at2759; -.
DR   PhylomeDB; Q8LE58; -.
DR   PRO; PR:Q8LE58; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8LE58; baseline and differential.
DR   Genevisible; Q8LE58; AT.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; HDA:TAIR.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0009793; P:embryo development ending in seed dormancy; IGI:TAIR.
DR   GO; GO:0000578; P:embryonic axis specification; IGI:TAIR.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IGI:TAIR.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   GO; GO:0090351; P:seedling development; IGI:TAIR.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   1: Evidence at protein level;
KW   Autophagy; Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..203
FT                   /note="ESCRT-related protein CHMP1A"
FT                   /id="PRO_0000433026"
FT   COILED          13..51
FT                   /evidence="ECO:0000255"
FT   COILED          109..140
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   203 AA;  22763 MW;  9BE8ECB35D4BB246 CRC64;
     MGNTDKLMNQ IFELKFTSKS LQRQARKCEK EERSEKLKVK KAIEKGNMDG ARIYAENAIR
     KRSEQMNYLR LSSRLDAVVA RLDTQAKMAT ITKSMTNIVK SLESSLTTGN LQKMSETMDS
     FEKQFVNMEV QAEFMDNAMA GSTSLSTPEG EVNSLMQQVA DDYGLEVSVG LPQPAGHAIP
     TKTEEKVEED DLTRRLAELK ARG
 
 
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