ID   CHM1A_XENLA             Reviewed;         196 AA.
AC   Q6NUD8;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Charged multivesicular body protein 1a;
DE   AltName: Full=Chromatin-modifying protein 1a;
DE            Short=CHMP1a;
GN   Name=chmp1a; Synonyms=pcoln3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III) which is
CC       involved in multivesicular bodies (MVBs) formation and sorting of
CC       endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles
CC       (ILVs) that are generated by invagination and scission from the
CC       limiting membrane of the endosome and mostly are delivered to lysosomes
CC       enabling degradation of membrane proteins, such as stimulated growth
CC       factor receptors, lysosomal enzymes and lipids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; BC068657; AAH68657.1; -; mRNA.
DR   RefSeq; NP_001084706.1; NM_001091237.1.
DR   AlphaFoldDB; Q6NUD8; -.
DR   SMR; Q6NUD8; -.
DR   DNASU; 414667; -.
DR   GeneID; 414667; -.
DR   KEGG; xla:414667; -.
DR   CTD; 414667; -.
DR   Xenbase; XB-GENE-5813040; chmp1a.S.
DR   OMA; KFASKQM; -.
DR   OrthoDB; 1441797at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 414667; Expressed in blastula and 19 other tissues.
DR   GO; GO:0000815; C:ESCRT III complex; IEA:InterPro.
DR   GO; GO:0016363; C:nuclear matrix; IEA:InterPro.
DR   GO; GO:0007076; P:mitotic chromosome condensation; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007034; P:vacuolar transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR029888; CHMP1A.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   PANTHER; PTHR10476:SF17; PTHR10476:SF17; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..196
FT                   /note="Charged multivesicular body protein 1a"
FT                   /id="PRO_0000211452"
FT   REGION          170..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          5..41
FT                   /evidence="ECO:0000255"
FT   MOTIF           185..195
FT                   /note="MIT-interacting motif"
SQ   SEQUENCE   196 AA;  21789 MW;  DFAC414780696B83 CRC64;
     MDDTLFQLKF TAKQLEKLAK KAEKDSNTEQ AKVKKALQQK NVEVARVYAE NAIRKKNEGL
     NWLRMASRVD AVASKVQTAV TMKGVTKNMA QVTKALDKAL SSMDLQKVSA VMDKFDQQVQ
     NLDVHTSVME DSMSSAMTLT TPQEQVDNLI VQIAEENGLE VMDQLNQLPQ GASSVGESST
     RTQEDQLSRR LASLRN