ID   CHM1B_CHICK             Reviewed;         199 AA.
AC   Q5ZKX1;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Charged multivesicular body protein 1b;
DE   AltName: Full=Chromatin-modifying protein 1b;
DE            Short=CHMP1b;
GN   Name=CHMP1B; ORFNames=RCJMB04_8n10;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III) which is
CC       involved in multivesicular bodies (MVBs) formation and sorting of
CC       endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles
CC       (ILVs) that are generated by invagination and scission from the
CC       limiting membrane of the endosome and mostly are delivered to lysosomes
CC       enabling degradation of membrane proteins, such as stimulated growth
CC       factor receptors, lysosomal enzymes and lipids.
CC   -!- SUBUNIT: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Endosome
CC       {ECO:0000250}. Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; AJ719963; CAG31622.1; -; mRNA.
DR   RefSeq; NP_001006428.1; NM_001006428.1.
DR   AlphaFoldDB; Q5ZKX1; -.
DR   SMR; Q5ZKX1; -.
DR   STRING; 9031.ENSGALP00000006490; -.
DR   PaxDb; Q5ZKX1; -.
DR   GeneID; 422143; -.
DR   KEGG; gga:422143; -.
DR   CTD; 57132; -.
DR   VEuPathDB; HostDB:geneid_422143; -.
DR   eggNOG; KOG3232; Eukaryota.
DR   InParanoid; Q5ZKX1; -.
DR   OrthoDB; 1441797at2759; -.
DR   PhylomeDB; Q5ZKX1; -.
DR   PRO; PR:Q5ZKX1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..199
FT                   /note="Charged multivesicular body protein 1b"
FT                   /id="PRO_0000211457"
FT   REGION          167..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          10..48
FT                   /evidence="ECO:0000255"
FT   COILED          178..199
FT                   /evidence="ECO:0000255"
FT   MOTIF           186..196
FT                   /note="MIT-interacting motif"
FT   COMPBIAS        168..186
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   199 AA;  22233 MW;  7841DFD3854E1EBE CRC64;
     MSNMEKHLFN LKFAAKELNR NSKRCDKEEK AEKAKIKKAI QKGNMEVARI HAENAIRQKN
     QAINFLRMSA RVDAVAARVQ TAVTMGKVTK SMAGVVKSMD ATLKSMNLEK ISALMDKFEH
     QFETLDVQTQ QMENTMSNTT TLTTPQNQVD MLLQEMADEA GLDLNMELPQ GQTGSVGTSV
     ASAEQDELSQ RLARLRDQV