ID   CHM1B_DANRE             Reviewed;         199 AA.
AC   Q7ZVB1;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Charged multivesicular body protein 1b;
DE   AltName: Full=Chromatin-modifying protein 1b;
DE            Short=CHMP1b;
GN   Name=chmp1b; ORFNames=zgc:56134;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III) which is
CC       involved in multivesicular bodies (MVBs) formation and sorting of
CC       endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles
CC       (ILVs) that are generated by invagination and scission from the
CC       limiting membrane of the endosome and mostly are delivered to lysosomes
CC       enabling degradation of membrane proteins, such as stimulated growth
CC       factor receptors, lysosomal enzymes and lipids.
CC   -!- SUBUNIT: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Endosome
CC       {ECO:0000250}. Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY398326; AAQ97759.1; -; mRNA.
DR   EMBL; BC045934; AAH45934.1; -; mRNA.
DR   EMBL; BC065462; AAH65462.1; -; mRNA.
DR   EMBL; BC067569; AAH67569.1; -; mRNA.
DR   RefSeq; NP_956308.1; NM_200014.1.
DR   RefSeq; XP_009299564.1; XM_009301289.2.
DR   AlphaFoldDB; Q7ZVB1; -.
DR   SMR; Q7ZVB1; -.
DR   Ensembl; ENSDART00000157900; ENSDARP00000141620; ENSDARG00000110691.
DR   Ensembl; ENSDART00000171199; ENSDARP00000134015; ENSDARG00000099624.
DR   GeneID; 336426; -.
DR   KEGG; dre:336426; -.
DR   CTD; 57132; -.
DR   ZFIN; ZDB-GENE-030131-8370; chmp1b.
DR   GeneTree; ENSGT00950000182832; -.
DR   HOGENOM; CLU_080826_0_1_1; -.
DR   InParanoid; Q7ZVB1; -.
DR   OMA; VMDRFET; -.
DR   OrthoDB; 1441797at2759; -.
DR   PhylomeDB; Q7ZVB1; -.
DR   PRO; PR:Q7ZVB1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000099624; Expressed in pharyngeal gill and 28 other tissues.
DR   ExpressionAtlas; Q7ZVB1; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..199
FT                   /note="Charged multivesicular body protein 1b"
FT                   /id="PRO_0000211458"
FT   REGION          167..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          10..30
FT                   /evidence="ECO:0000255"
FT   COILED          178..199
FT                   /evidence="ECO:0000255"
FT   MOTIF           186..196
FT                   /note="MIT-interacting motif"
FT   COMPBIAS        168..186
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   199 AA;  22063 MW;  880EE28120DC1862 CRC64;
     MSSMEKHLFN LKFAAKELQR NSKKCDKEEK AEKVKVKKAI QKGNMEVARI HAENAIRQKN
     QSVNFLRMSA RVDAVAARVQ TAVTMNQVTK SMAGVVKGMD ATLKSMNLEK ISGLMEKFER
     QFETLDVQTA QMEDSMSSTT TLTTPQGQVD TLMMEMADEA GLDLNMELPQ GQTGSVGTSV
     ASAEQDELSQ RLAKLRDQV