ID   CHM2A_CHICK             Reviewed;         220 AA.
AC   Q5ZHN1;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Charged multivesicular body protein 2a;
DE   AltName: Full=Chromatin-modifying protein 2a;
DE            Short=CHMP2a;
GN   Name=CHMP2A; ORFNames=RCJMB04_35d23;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III) which is involved in multivesicular
CC       bodies (MVBs) formation and sorting of endosomal cargo proteins into
CC       MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by
CC       invagination and scission from the limiting membrane of the endosome
CC       and mostly are delivered to lysosomes enabling degradation of membrane
CC       proteins, such as stimulated growth factor receptors, lysosomal enzymes
CC       and lipids (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III). ESCRT-III components are thought to
CC       multimerize to form a flat lattice on the perimeter membrane of the
CC       endosome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; AJ721103; CAG32762.1; -; mRNA.
DR   RefSeq; NP_001074361.1; NM_001080892.1.
DR   AlphaFoldDB; Q5ZHN1; -.
DR   SMR; Q5ZHN1; -.
DR   STRING; 9031.ENSGALP00000043054; -.
DR   PaxDb; Q5ZHN1; -.
DR   PRIDE; Q5ZHN1; -.
DR   GeneID; 776036; -.
DR   KEGG; gga:776036; -.
DR   CTD; 27243; -.
DR   VEuPathDB; HostDB:geneid_776036; -.
DR   eggNOG; KOG3230; Eukaryota.
DR   InParanoid; Q5ZHN1; -.
DR   OrthoDB; 1254120at2759; -.
DR   PhylomeDB; Q5ZHN1; -.
DR   PRO; PR:Q5ZHN1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0010458; P:exit from mitosis; ISS:UniProtKB.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0031468; P:nuclear membrane reassembly; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..220
FT                   /note="Charged multivesicular body protein 2a"
FT                   /id="PRO_0000211464"
FT   COILED          12..52
FT                   /evidence="ECO:0000255"
FT   COILED          195..220
FT                   /evidence="ECO:0000255"
FT   MOTIF           208..218
FT                   /note="MIT-interacting motif"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   220 AA;  24733 MW;  278ADE4F5364245D CRC64;
     MDLLFGRRKT PEELLRQNQR ALTRAMRELD RERQKLEAQE KKIIIDIKKM AKQGQMDAVK
     IMAKDLVRTR RYVKKFITMR ANVQAVSLKI QTLKSNNSMA LAMKGVTKAM ATMNRQLKLP
     QIQKIMMEFE KQAGIMDMKE ELMNDAIDDA MGDEDDEEES DAVVSQVLDE LGLNLTDELA
     TLPPPGGSLA AGEGRAAEAA AALADADADL EERLKNLRRD