ID   CHM2A_DANRE             Reviewed;         220 AA.
AC   Q7ZW25;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Charged multivesicular body protein 2a;
DE   AltName: Full=Chromatin-modifying protein 2a;
DE            Short=CHMP2a;
GN   Name=chmp2a; Synonyms=bc2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III) which is involved in multivesicular
CC       bodies (MVBs) formation and sorting of endosomal cargo proteins into
CC       MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by
CC       invagination and scission from the limiting membrane of the endosome
CC       and mostly are delivered to lysosomes enabling degradation of membrane
CC       proteins, such as stimulated growth factor receptors, lysosomal enzymes
CC       and lipids (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III). ESCRT-III components are thought to
CC       multimerize to form a flat lattice on the perimeter membrane of the
CC       endosome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; BC045320; AAH45320.1; -; mRNA.
DR   RefSeq; NP_998682.1; NM_213517.1.
DR   AlphaFoldDB; Q7ZW25; -.
DR   SMR; Q7ZW25; -.
DR   STRING; 7955.ENSDARP00000070582; -.
DR   PaxDb; Q7ZW25; -.
DR   GeneID; 798901; -.
DR   KEGG; dre:798901; -.
DR   CTD; 27243; -.
DR   ZFIN; ZDB-GENE-040426-2922; chmp2a.
DR   eggNOG; KOG3230; Eukaryota.
DR   InParanoid; Q7ZW25; -.
DR   OrthoDB; 1254120at2759; -.
DR   PhylomeDB; Q7ZW25; -.
DR   Reactome; R-DRE-1632852; Macroautophagy.
DR   Reactome; R-DRE-432720; Lysosome Vesicle Biogenesis.
DR   Reactome; R-DRE-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   Reactome; R-DRE-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   PRO; PR:Q7ZW25; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0010458; P:exit from mitosis; ISS:UniProtKB.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0031468; P:nuclear membrane reassembly; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..220
FT                   /note="Charged multivesicular body protein 2a"
FT                   /id="PRO_0000211465"
FT   REGION          184..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          12..53
FT                   /evidence="ECO:0000255"
FT   MOTIF           208..218
FT                   /note="MIT-interacting motif"
FT   COMPBIAS        206..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   220 AA;  25108 MW;  F8DE65002DF94F75 CRC64;
     MESLFGRRKT PEEMLRQNQR ALNRAMRDLD RERQRLEQQE KKIIADIKKM AKQGQMDAVK
     IMAKDLVRTR RYVKKFIMMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM ATMNRQLKLP
     QIQKIMMEFE RQSEIMDMKE EMMNDAIDDA MGDEDDEEES DAVVSQVLDE LGLTLSDELS
     NLPATGGSLS VAAGKKAEPQ PTLADADADL EERLNNLRRD