ID   CHM2A_XENTR             Reviewed;         220 AA.
AC   Q6DFS6; Q28E86;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Charged multivesicular body protein 2a;
DE   AltName: Full=Chromatin-modifying protein 2a;
DE            Short=CHMP2a;
GN   Name=chmp2a; ORFNames=TNeu078g14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III) which is involved in multivesicular
CC       bodies (MVBs) formation and sorting of endosomal cargo proteins into
CC       MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by
CC       invagination and scission from the limiting membrane of the endosome
CC       and mostly are delivered to lysosomes enabling degradation of membrane
CC       proteins, such as stimulated growth factor receptors, lysosomal enzymes
CC       and lipids (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III). ESCRT-III components are thought to
CC       multimerize to form a flat lattice on the perimeter membrane of the
CC       endosome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; CR848397; CAJ82871.1; -; mRNA.
DR   EMBL; BC076657; AAH76657.1; -; mRNA.
DR   EMBL; BC082521; AAH82521.1; -; mRNA.
DR   RefSeq; NP_001005008.1; NM_001005008.1.
DR   RefSeq; XP_012821866.1; XM_012966412.2.
DR   AlphaFoldDB; Q6DFS6; -.
DR   SMR; Q6DFS6; -.
DR   STRING; 8364.ENSXETP00000041697; -.
DR   PaxDb; Q6DFS6; -.
DR   DNASU; 448496; -.
DR   Ensembl; ENSXETT00000041697; ENSXETP00000041697; ENSXETG00000019244.
DR   GeneID; 448496; -.
DR   KEGG; xtr:448496; -.
DR   CTD; 27243; -.
DR   Xenbase; XB-GENE-1005459; chmp2a.
DR   eggNOG; KOG3230; Eukaryota.
DR   HOGENOM; CLU_069208_1_0_1; -.
DR   InParanoid; Q6DFS6; -.
DR   OMA; MQDFERQ; -.
DR   OrthoDB; 1254120at2759; -.
DR   PhylomeDB; Q6DFS6; -.
DR   TreeFam; TF300118; -.
DR   Reactome; R-XTR-1632852; Macroautophagy.
DR   Reactome; R-XTR-432720; Lysosome Vesicle Biogenesis.
DR   Reactome; R-XTR-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000019244; Expressed in testis and 18 other tissues.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0010458; P:exit from mitosis; ISS:UniProtKB.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0031468; P:nuclear membrane reassembly; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..220
FT                   /note="Charged multivesicular body protein 2a"
FT                   /id="PRO_0000211467"
FT   REGION          179..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          12..53
FT                   /evidence="ECO:0000255"
FT   COILED          199..220
FT                   /evidence="ECO:0000255"
FT   MOTIF           208..218
FT                   /note="MIT-interacting motif"
SQ   SEQUENCE   220 AA;  25035 MW;  5370797516C00AEF CRC64;
     MEFLFGRRKT PEEMLRQNQR ALNKAMREMD RERQKLEQQE KKIIADIKKM AKQGQMDAVK
     IMAKDLVRTR RYVKKFIMMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM ATMNRQLKLP
     QIQKIMMEFE KQSEIMDMKE EMMNDAIDDA MGDEDDEEES DAVVSQVLDE LGLTLTDELS
     NLPSTGGSLS VAGAKKGEPS AALADADADL EERLNNLRRD