ID   CHM4B_CHICK             Reviewed;         227 AA.
AC   Q5ZHP5;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Charged multivesicular body protein 4b;
DE   AltName: Full=Chromatin-modifying protein 4b;
DE            Short=CHMP4b;
GN   Name=CHMP4B; ORFNames=RCJMB04_34n7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III) which is involved in multivesicular
CC       bodies (MVBs) formation and sorting of endosomal cargo proteins into
CC       MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by
CC       invagination and scission from the limiting membrane of the endosome
CC       and mostly are delivered to lysosomes enabling degradation of membrane
CC       proteins, such as stimulated growth factor receptors, lysosomal enzymes
CC       and lipids (By similarity). {ECO:0000250|UniProtKB:Q9H444}.
CC   -!- SUBUNIT: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III). ESCRT-III components are thought to
CC       multimerize to form a flat lattice on the perimeter membrane of the
CC       endosome (By similarity). {ECO:0000250|UniProtKB:Q9H444}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9H444}. Late endosome membrane
CC       {ECO:0000250|UniProtKB:Q9H444}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9H444}. Midbody {ECO:0000250|UniProtKB:Q9H444}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; AJ721089; CAG32748.1; -; mRNA.
DR   RefSeq; NP_001006286.1; NM_001006286.1.
DR   AlphaFoldDB; Q5ZHP5; -.
DR   SMR; Q5ZHP5; -.
DR   BioGRID; 680303; 1.
DR   IntAct; Q5ZHP5; 1.
DR   STRING; 9031.ENSGALP00000003263; -.
DR   PaxDb; Q5ZHP5; -.
DR   Ensembl; ENSGALT00000003268; ENSGALP00000003263; ENSGALG00000002095.
DR   GeneID; 419150; -.
DR   KEGG; gga:419150; -.
DR   CTD; 128866; -.
DR   VEuPathDB; HostDB:geneid_419150; -.
DR   eggNOG; KOG1656; Eukaryota.
DR   GeneTree; ENSGT00940000154663; -.
DR   HOGENOM; CLU_071097_0_0_1; -.
DR   InParanoid; Q5ZHP5; -.
DR   OMA; WSWFGGA; -.
DR   OrthoDB; 1490465at2759; -.
DR   PhylomeDB; Q5ZHP5; -.
DR   TreeFam; TF314269; -.
DR   Reactome; R-GGA-1632852; Macroautophagy.
DR   Reactome; R-GGA-5620971; Pyroptosis.
DR   Reactome; R-GGA-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   Reactome; R-GGA-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   PRO; PR:Q5ZHP5; -.
DR   Proteomes; UP000000539; Chromosome 20.
DR   Bgee; ENSGALG00000002095; Expressed in ovary and 14 other tissues.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000815; C:ESCRT III complex; ISS:UniProtKB.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0010458; P:exit from mitosis; ISS:UniProtKB.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0090148; P:membrane fission; ISS:UniProtKB.
DR   GO; GO:0000281; P:mitotic cytokinesis; ISS:UniProtKB.
DR   GO; GO:0031468; P:nuclear membrane reassembly; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..227
FT                   /note="Charged multivesicular body protein 4b"
FT                   /id="PRO_0000211491"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          25..185
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   227 AA;  25155 MW;  F3546CA93137DF7B CRC64;
     MSGILGKLFG AGAGGKGAGK GPSPQEAIQR LRDTEEMLSK KQEFLEKKIE QELAAARKHG
     TKNKRAALQA LKRKKRYEKQ LAQIDGTLST IEFQREALEN ANTNTEVLKN MGFAAKAMKA
     AHDNMDIDKV DELMQDIAEQ QELADEISTA ISKPVGFGEE FDEDELMAEL EELEQEELDK
     NLLEISGPET VPLPNVPSIS IPSKPAKKKE EEEDDDMKEL EAWAGNM