ID   CHM4B_XENTR             Reviewed;         222 AA.
AC   Q6GL11; Q28EX8;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Charged multivesicular body protein 4b;
DE   AltName: Full=Chromatin-modifying protein 4b;
DE            Short=CHMP4b;
GN   Name=chmp4b; ORFNames=TGas124e08.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III) which is involved in multivesicular
CC       bodies (MVBs) formation and sorting of endosomal cargo proteins into
CC       MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by
CC       invagination and scission from the limiting membrane of the endosome
CC       and mostly are delivered to lysosomes enabling degradation of membrane
CC       proteins, such as stimulated growth factor receptors, lysosomal enzymes
CC       and lipids (By similarity). {ECO:0000250|UniProtKB:Q9H444}.
CC   -!- SUBUNIT: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III). ESCRT-III components are thought to
CC       multimerize to form a flat lattice on the perimeter membrane of the
CC       endosome (By similarity). {ECO:0000250|UniProtKB:Q9H444}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9H444}. Late endosome membrane
CC       {ECO:0000250|UniProtKB:Q9H444}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9H444}. Midbody {ECO:0000250|UniProtKB:Q9H444}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; CR762287; CAJ83591.1; -; mRNA.
DR   EMBL; BC074708; AAH74708.1; -; mRNA.
DR   RefSeq; NP_001004866.1; NM_001004866.1.
DR   AlphaFoldDB; Q6GL11; -.
DR   SMR; Q6GL11; -.
DR   STRING; 8364.ENSXETP00000060482; -.
DR   DNASU; 448169; -.
DR   GeneID; 448169; -.
DR   KEGG; xtr:448169; -.
DR   CTD; 128866; -.
DR   Xenbase; XB-GENE-941865; chmp4b.
DR   eggNOG; KOG1656; Eukaryota.
DR   InParanoid; Q6GL11; -.
DR   OrthoDB; 1490465at2759; -.
DR   Reactome; R-XTR-1632852; Macroautophagy.
DR   Reactome; R-XTR-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000815; C:ESCRT III complex; ISS:UniProtKB.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0010458; P:exit from mitosis; ISS:UniProtKB.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0090148; P:membrane fission; ISS:UniProtKB.
DR   GO; GO:0000281; P:mitotic cytokinesis; ISS:UniProtKB.
DR   GO; GO:0031468; P:nuclear membrane reassembly; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..222
FT                   /note="Charged multivesicular body protein 4b"
FT                   /id="PRO_0000211494"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          21..182
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   222 AA;  24891 MW;  0260C9DA2A3FD29D CRC64;
     MSLIGKLFGT GGKGAKGPSP QEAIQKLRDT EEMLTKKQEF LEKKIEQELV TAKKHGTKNK
     RAALQALKRK KRYEKQLAQI DGTLSTIEFQ REALENANTN TEVLKNMGFA AKAMKAAHDN
     MDIEKVDELM QDIADQQELA QEISDAISKP VGFGEDFDED ELMAELEELE QEELDKNLLE
     VQGPETVPLP NVPAAVLPAK PVKKKQEEDD DDMRELENWA TA