ID   CHM4C_DANRE             Reviewed;         224 AA.
AC   Q6IQ73; Q803U4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Charged multivesicular body protein 4c;
DE   AltName: Full=Chromatin-modifying protein 4c;
DE            Short=CHMP4c;
GN   Name=chmp4c; Synonyms=chmp4b; ORFNames=zgc:55566;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III) which is involved in multivesicular
CC       bodies (MVBs) formation and sorting of endosomal cargo proteins into
CC       MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by
CC       invagination and scission from the limiting membrane of the endosome
CC       and mostly are delivered to lysosomes enabling degradation of membrane
CC       proteins, such as stimulated growth factor receptors, lysosomal enzymes
CC       and lipids. Key component of the cytokinesis checkpoint, a process
CC       required to delay abscission to prevent both premature resolution of
CC       intercellular chromosome bridges and accumulation of DNA damage (By
CC       similarity). {ECO:0000250|UniProtKB:Q96CF2}.
CC   -!- SUBUNIT: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III). ESCRT-III components are thought to
CC       multimerize to form a flat lattice on the perimeter membrane of the
CC       endosome (By similarity). {ECO:0000250|UniProtKB:Q96CF2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Late endosome
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; BC044191; AAH44191.1; -; mRNA.
DR   EMBL; BC071537; AAH71537.1; -; mRNA.
DR   RefSeq; NP_998622.1; NM_213457.1.
DR   AlphaFoldDB; Q6IQ73; -.
DR   SMR; Q6IQ73; -.
DR   STRING; 7955.ENSDARP00000023938; -.
DR   PaxDb; Q6IQ73; -.
DR   PRIDE; Q6IQ73; -.
DR   Ensembl; ENSDART00000015193; ENSDARP00000023938; ENSDARG00000007323.
DR   GeneID; 406766; -.
DR   KEGG; dre:406766; -.
DR   CTD; 406766; -.
DR   ZFIN; ZDB-GENE-040426-2812; chmp4bb.
DR   eggNOG; KOG1656; Eukaryota.
DR   GeneTree; ENSGT00940000154663; -.
DR   HOGENOM; CLU_071097_0_0_1; -.
DR   InParanoid; Q6IQ73; -.
DR   OMA; QHMDVDQ; -.
DR   OrthoDB; 1490465at2759; -.
DR   PhylomeDB; Q6IQ73; -.
DR   TreeFam; TF314269; -.
DR   Reactome; R-DRE-1632852; Macroautophagy.
DR   Reactome; R-DRE-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   Reactome; R-DRE-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   PRO; PR:Q6IQ73; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000007323; Expressed in swim bladder and 28 other tissues.
DR   ExpressionAtlas; Q6IQ73; baseline and differential.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0009838; P:abscission; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; IGI:ZFIN.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0044878; P:mitotic cytokinesis checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0032466; P:negative regulation of cytokinesis; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..224
FT                   /note="Charged multivesicular body protein 4c"
FT                   /id="PRO_0000211498"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          21..221
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        203..224
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        36
FT                   /note="K -> E (in Ref. 1; AAH44191)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   224 AA;  25176 MW;  1C2E48B7133A8023 CRC64;
     MSVFGKLFGG GGKGGKGPTP QEAIQKLRET EEMLAKKQDF LEKKIDAELL IAKKNGTKNK
     RAALQALKRK KRYEKQLAQI DGTLSTIEFQ REALENANTN TEVLKNMGFA AKAMKTAHEN
     MDIDKVDDLM QDITEQQELA QEISDAISRP VGFGEEFDED ELMAELEELE QEELDKDLLQ
     ISGPEDVPLP NVPSNPLPKK TAVAQKKRQE EDEDDMEELK AWAM