ID   CHMP1_DICDI             Reviewed;         192 AA.
AC   O96552; Q55F99;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Charged multivesicular body protein 1;
DE   AltName: Full=Developmental gene 1118 protein;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 46;
GN   Name=chmp1; Synonyms=DG1118, vps46; ORFNames=DDB_G0267394;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AX4;
RA   Iranfar N., Loomis W.F.;
RT   "Dictyostelium discoideum developmental gene DG1118.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III) which is
CC       involved in multivesicular bodies (MVBs) formation and sorting of
CC       endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles
CC       (ILVs) that are generated by invagination and scission from the
CC       limiting membrane of the endosome and are delivered to lysosomes
CC       enabling degradation of membrane proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; AF081802; AAC67541.1; -; Genomic_DNA.
DR   EMBL; AAFI02000003; EAL73149.1; -; Genomic_DNA.
DR   RefSeq; XP_647634.1; XM_642542.1.
DR   AlphaFoldDB; O96552; -.
DR   SMR; O96552; -.
DR   STRING; 44689.DDB0191317; -.
DR   PaxDb; O96552; -.
DR   EnsemblProtists; EAL73149; EAL73149; DDB_G0267394.
DR   GeneID; 8616449; -.
DR   KEGG; ddi:DDB_G0267394; -.
DR   dictyBase; DDB_G0267394; vps46.
DR   eggNOG; KOG3232; Eukaryota.
DR   HOGENOM; CLU_080826_1_0_1; -.
DR   InParanoid; O96552; -.
DR   OMA; KFASKQM; -.
DR   PhylomeDB; O96552; -.
DR   PRO; PR:O96552; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; ISS:dictyBase.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0005770; C:late endosome; ISS:dictyBase.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0045324; P:late endosome to vacuole transport; ISS:dictyBase.
DR   GO; GO:0006623; P:protein targeting to vacuole; ISS:dictyBase.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..192
FT                   /note="Charged multivesicular body protein 1"
FT                   /id="PRO_0000367439"
FT   REGION          164..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          7..35
FT                   /evidence="ECO:0000255"
FT   COILED          102..125
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        176..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   192 AA;  21835 MW;  3583A15AB09D64A1 CRC64;
     MENQLFQLKF TSKQLEKQSK KSEQSEKAQK IKLKKAIEQG NMDGARIYAQ NAIREKNQSL
     NYLRLASRID AVASRVETAI RMKSVTGSMA NIVKSMEKSM RNMDLEKITQ VMDQFERQFE
     DLDVQSVYVE NAMNQTTTLS TPADQVDLLI SQVADEHGLN VGMQMGSAPS EKVQQGETDE
     LTERLNRLKQ KN