ID   CHMP3_DICDI             Reviewed;         207 AA.
AC   Q54P63;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Charged multivesicular body protein 3;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 24;
GN   Name=chmp3; Synonyms=vps24; ORFNames=DDB_G0284769;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III) which is involved in multivesicular
CC       bodies (MVBs) formation and sorting of endosomal cargo proteins into
CC       MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by
CC       invagination and scission from the limiting membrane of the endosome
CC       and are delivered to lysosomes enabling degradation of membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; AAFI02000071; EAL65037.1; -; Genomic_DNA.
DR   RefSeq; XP_638395.1; XM_633303.1.
DR   AlphaFoldDB; Q54P63; -.
DR   SMR; Q54P63; -.
DR   STRING; 44689.DDB0234036; -.
DR   PaxDb; Q54P63; -.
DR   EnsemblProtists; EAL65037; EAL65037; DDB_G0284769.
DR   GeneID; 8624764; -.
DR   KEGG; ddi:DDB_G0284769; -.
DR   dictyBase; DDB_G0284769; vps24.
DR   eggNOG; KOG3229; Eukaryota.
DR   HOGENOM; CLU_069208_0_2_1; -.
DR   InParanoid; Q54P63; -.
DR   OMA; INEMMDD; -.
DR   PhylomeDB; Q54P63; -.
DR   Reactome; R-DDI-1632852; Macroautophagy.
DR   Reactome; R-DDI-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   Reactome; R-DDI-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   PRO; PR:Q54P63; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0000815; C:ESCRT III complex; ISS:dictyBase.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..207
FT                   /note="Charged multivesicular body protein 3"
FT                   /id="PRO_0000367440"
FT   REGION          174..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          183..207
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        185..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   207 AA;  23741 MW;  DB8E1E522FFD8246 CRC64;
     MFSFLKKPTP EELVKKWKRE LRREDRGLDT QLRAIDMQEK KTVRMIKERV KAGDQKSAKT
     LAKEIVNSRK AKERIYTAKA QMNSVSMQLQ SNLAMTKVQG NLAKSTEIMK MMNDLIKLPE
     LNKVMMAMGS EMTKAGIMEE MISDVFDMQG EDLEEEAEME VNKIMDEILV SGPQVSSAPL
     ETHQQEEVVQ EKQEDSELLD RLKALKS