CHMP5_DANRE
ID CHMP5_DANRE Reviewed; 220 AA.
AC Q7T339;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Charged multivesicular body protein 5;
DE AltName: Full=Chromatin-modifying protein 5;
GN Name=chmp5;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable peripherally associated component of the endosomal
CC sorting required for transport complex III (ESCRT-III) which is
CC involved in multivesicular bodies (MVBs) formation and sorting of
CC endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles
CC (ILVs) that are generated by invagination and scission from the
CC limiting membrane of the endosome and mostly are delivered to lysosomes
CC enabling degradation of membrane proteins, such as stimulated growth
CC factor receptors, lysosomal enzymes and lipids (By similarity).
CC {ECO:0000250|UniProtKB:Q9NZZ3}.
CC -!- SUBUNIT: Probable peripherally associated component of the endosomal
CC sorting required for transport complex III (ESCRT-III).
CC {ECO:0000250|UniProtKB:Q9NZZ3}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q9NZZ3}. Endosome membrane {ECO:0000305};
CC Peripheral membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR EMBL; BC053265; AAH53265.1; -; mRNA.
DR RefSeq; NP_956674.1; NM_200380.1.
DR AlphaFoldDB; Q7T339; -.
DR SMR; Q7T339; -.
DR STRING; 7955.ENSDARP00000061395; -.
DR PaxDb; Q7T339; -.
DR PRIDE; Q7T339; -.
DR Ensembl; ENSDART00000165390; ENSDARP00000138817; ENSDARG00000103718.
DR GeneID; 393351; -.
DR KEGG; dre:393351; -.
DR CTD; 393351; -.
DR ZFIN; ZDB-GENE-040426-1374; chmp5b.
DR eggNOG; KOG1655; Eukaryota.
DR GeneTree; ENSGT00550000074817; -.
DR HOGENOM; CLU_079409_1_0_1; -.
DR InParanoid; Q7T339; -.
DR OMA; MEQAQTM; -.
DR OrthoDB; 1301560at2759; -.
DR PhylomeDB; Q7T339; -.
DR TreeFam; TF300122; -.
DR Reactome; R-DRE-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR PRO; PR:Q7T339; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 7.
DR Bgee; ENSDARG00000103718; Expressed in testis and 31 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR InterPro; IPR005024; Snf7_fam.
DR PANTHER; PTHR22761; PTHR22761; 1.
DR Pfam; PF03357; Snf7; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..220
FT /note="Charged multivesicular body protein 5"
FT /id="PRO_0000211504"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 25..55
FT /evidence="ECO:0000255"
FT COILED 121..153
FT /evidence="ECO:0000255"
SQ SEQUENCE 220 AA; 24769 MW; 2EC9DD7ABE68C4AD CRC64;
MNRIFGRGKP KGPPPNLTDC ISGVDSRAES VDKKIARLDA ELMKYKDQMK KMRDGPSKNM
VKQKAMRVLK QKRMYEGQRD QLMQQSFNME QANYTIQTLK DTKTTVEAMK IGAKEMKKAY
KNVKIDQIED LQDQLEDMME DANEVQEALS RSYGTPEIDE DDLEAELDAL GDELLLDDDN
SYLDEASSAP AIPEGAPGDR TTNRDGVLVD EFGLPQIPAT