ID   CHMP5_DICDI             Reviewed;         215 AA.
AC   Q54JK4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Charged multivesicular body protein 5;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 60;
GN   Name=chmp5; Synonyms=vps60; ORFNames=DDB_G0287993;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III) which is
CC       involved in multivesicular bodies (MVBs) formation and sorting of
CC       endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles
CC       (ILVs) that are generated by invagination and scission from the
CC       limiting membrane of the endosome and are delivered to lysosomes
CC       enabling degradation of membrane proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; AAFI02000107; EAL63422.1; -; Genomic_DNA.
DR   RefSeq; XP_636927.1; XM_631835.1.
DR   AlphaFoldDB; Q54JK4; -.
DR   SMR; Q54JK4; -.
DR   STRING; 44689.DDB0234057; -.
DR   PaxDb; Q54JK4; -.
DR   PRIDE; Q54JK4; -.
DR   EnsemblProtists; EAL63422; EAL63422; DDB_G0287993.
DR   GeneID; 8626402; -.
DR   KEGG; ddi:DDB_G0287993; -.
DR   dictyBase; DDB_G0287993; vps60.
DR   eggNOG; KOG1655; Eukaryota.
DR   HOGENOM; CLU_079409_1_0_1; -.
DR   InParanoid; Q54JK4; -.
DR   OMA; MEQAQTM; -.
DR   PhylomeDB; Q54JK4; -.
DR   Reactome; R-DDI-1632852; Macroautophagy.
DR   Reactome; R-DDI-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   Reactome; R-DDI-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   PRO; PR:Q54JK4; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..215
FT                   /note="Charged multivesicular body protein 5"
FT                   /id="PRO_0000367441"
FT   REGION          186..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          29..81
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   215 AA;  24319 MW;  2AC9560CED243FCC CRC64;
     MKRFFGVSNN QPAPTLDEAT KRIGGRMGQM DEKINGLNQE LLAYDKQIKA TRPGPAQNAI
     KQKAIRVLQQ KKMYERQRDQ MASTSFNMEQ TKFATESMRD TITTVSAMKQ GAKDMKTQLK
     HIKIEDVDDM QDEMQDLLDY NNEIQESLGR AYQTPDTLDE SELEAELMSM GEELELEASM
     PSYLMTPSVP TTDPHQSSVD EYGLPIGQEA SQQVV