ID   CHMP5_XENLA             Reviewed;         219 AA.
AC   Q6DD52;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Charged multivesicular body protein 5;
DE   AltName: Full=Chromatin-modifying protein 5;
GN   Name=chmp5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III) which is
CC       involved in multivesicular bodies (MVBs) formation and sorting of
CC       endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles
CC       (ILVs) that are generated by invagination and scission from the
CC       limiting membrane of the endosome and mostly are delivered to lysosomes
CC       enabling degradation of membrane proteins, such as stimulated growth
CC       factor receptors, lysosomal enzymes and lipids (By similarity).
CC       {ECO:0000250|UniProtKB:Q9NZZ3}.
CC   -!- SUBUNIT: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III).
CC       {ECO:0000250|UniProtKB:Q9NZZ3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9NZZ3}. Endosome membrane {ECO:0000305};
CC       Peripheral membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; BC077776; AAH77776.1; -; mRNA.
DR   RefSeq; NP_001086926.1; NM_001093457.1.
DR   AlphaFoldDB; Q6DD52; -.
DR   SMR; Q6DD52; -.
DR   MaxQB; Q6DD52; -.
DR   DNASU; 446761; -.
DR   GeneID; 446761; -.
DR   KEGG; xla:446761; -.
DR   CTD; 446761; -.
DR   Xenbase; XB-GENE-5962886; chmp5.L.
DR   OMA; MEQAQTM; -.
DR   OrthoDB; 1301560at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 446761; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007034; P:vacuolar transport; IEA:InterPro.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..219
FT                   /note="Charged multivesicular body protein 5"
FT                   /id="PRO_0000211505"
FT   COILED          22..153
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  24787 MW;  1A9961B53199E9D4 CRC64;
     MNRIFGKSKP KVPPPTLTDC ITNVDGRAES IEKKISRLDA ELIKYKDQMK KMREGPSKNM
     VKQKALRVLK QKRMYEQQRD NLNQQSFNME QANYTIQTLK DTKTTVDAMK VGAKEMKKAY
     KQVKIDQIED LQDQLEDMME NANEIQEALS RSYGTPEIDE DDLEAELDAL GDELLLDDDT
     SYLDEAASAP AIPEGVPNDS KNKDGVLVDE FGLPQIPAT