ID   CHMP5_XENTR             Reviewed;         219 AA.
AC   Q5FW29; Q05B07; Q28CX3;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Charged multivesicular body protein 5;
DE   AltName: Full=Chromatin-modifying protein 5;
GN   Name=chmp5; ORFNames=TTpA012b21.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Skeletal muscle;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III) which is
CC       involved in multivesicular bodies (MVBs) formation and sorting of
CC       endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles
CC       (ILVs) that are generated by invagination and scission from the
CC       limiting membrane of the endosome and mostly are delivered to lysosomes
CC       enabling degradation of membrane proteins, such as stimulated growth
CC       factor receptors, lysosomal enzymes and lipids (By similarity).
CC       {ECO:0000250|UniProtKB:Q9NZZ3}.
CC   -!- SUBUNIT: Probable peripherally associated component of the endosomal
CC       sorting required for transport complex III (ESCRT-III).
CC       {ECO:0000250|UniProtKB:Q9NZZ3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9NZZ3}. Endosome membrane {ECO:0000305};
CC       Peripheral membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; CR855823; CAJ83138.1; -; mRNA.
DR   EMBL; BC089652; AAH89652.1; -; mRNA.
DR   EMBL; BC123040; AAI23041.1; -; mRNA.
DR   RefSeq; NP_001016748.1; NM_001016748.2.
DR   AlphaFoldDB; Q5FW29; -.
DR   SMR; Q5FW29; -.
DR   STRING; 8364.ENSXETP00000045646; -.
DR   Ensembl; ENSXETT00000072662; ENSXETP00000078318; ENSXETG00000004991.
DR   GeneID; 549502; -.
DR   KEGG; xtr:549502; -.
DR   CTD; 51510; -.
DR   Xenbase; XB-GENE-5962693; chmp5.
DR   eggNOG; KOG1655; Eukaryota.
DR   InParanoid; Q5FW29; -.
DR   OrthoDB; 1301560at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004991; Expressed in heart and 15 other tissues.
DR   ExpressionAtlas; Q5FW29; baseline.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..219
FT                   /note="Charged multivesicular body protein 5"
FT                   /id="PRO_0000211506"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          28..153
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  24767 MW;  7A237AE62491CA2A CRC64;
     MNRLFGKSKP KVPPSTLTDC ISNVDSRSES IDKKISRLDA ELVKYKDQMK KMREGPSKNM
     VKQKALRVLK QKRMYEQQRD NLNQQSFNME QTNYAIQSLK DTKTTVDAMK VGAKEMKKAY
     KQVKIDQIED LQDQLEDMME NANEIQEALS RSYGTPEIDE DDLEAELDAL GDELLLDDDT
     SYLDEAASAP AIPEGVPNDS KNKDGVLVDE FGLPQIPAT