ID   CHMP6_DICDI             Reviewed;         218 AA.
AC   Q54KZ4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Charged multivesicular body protein 6;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 20;
GN   Name=chmp6; Synonyms=vps20; ORFNames=DDB_G0287021;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III) which is involved in multivesicular
CC       bodies (MVBs) formation and sorting of endosomal cargo proteins into
CC       MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by
CC       invagination and scission from the limiting membrane of the endosome
CC       and are delivered to lysosomes enabling degradation of membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL63937.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAFI02000095; EAL63937.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_637438.1; XM_632346.1.
DR   AlphaFoldDB; Q54KZ4; -.
DR   SMR; Q54KZ4; -.
DR   STRING; 44689.DDB0234035; -.
DR   PaxDb; Q54KZ4; -.
DR   EnsemblProtists; EAL63937; EAL63937; DDB_G0287021.
DR   GeneID; 8625906; -.
DR   KEGG; ddi:DDB_G0287021; -.
DR   dictyBase; DDB_G0287021; vps20.
DR   eggNOG; KOG2910; Eukaryota.
DR   InParanoid; Q54KZ4; -.
DR   Reactome; R-DDI-1632852; Macroautophagy.
DR   Reactome; R-DDI-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR   Reactome; R-DDI-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   PRO; PR:Q54KZ4; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0000815; C:ESCRT III complex; ISS:dictyBase.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..218
FT                   /note="Charged multivesicular body protein 6"
FT                   /id="PRO_0000367442"
FT   COILED          15..42
FT                   /evidence="ECO:0000255"
FT   COILED          70..172
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   218 AA;  24947 MW;  99C137BAE66E808B CRC64;
     MGILFSHCSG GREKEDKISK TDRAVLNLKI QRDKLKNYQT QVLEIAIAKE CSKAGKKNQA
     LLALKKKKYQ EKMLDESFAN LQNIEELIAN VEQAEIQVRI FESLKQGNES LKEIQKEMSL
     EDVENLMEET AEAIQYQNDI SEALSGKFSK EEEDDLLNEL DEMEKQLNAQ QYPKVPETQL
     PKIELPIEDA IEEGKQRKST TNGLNHILII ACIINHIF