ID   CHMP7_DICDI             Reviewed;         477 AA.
AC   Q86K93; Q550D9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Charged multivesicular body protein 7;
GN   Name=chmp7; ORFNames=DDB_G0277133;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Plays a role in the endosomal sorting pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; AAFI02000019; EAL68878.1; -; Genomic_DNA.
DR   RefSeq; XP_642803.1; XM_637711.1.
DR   AlphaFoldDB; Q86K93; -.
DR   SMR; Q86K93; -.
DR   STRING; 44689.DDB0266400; -.
DR   PaxDb; Q86K93; -.
DR   EnsemblProtists; EAL68878; EAL68878; DDB_G0277133.
DR   GeneID; 8620866; -.
DR   KEGG; ddi:DDB_G0277133; -.
DR   dictyBase; DDB_G0277133; -.
DR   eggNOG; KOG2911; Eukaryota.
DR   HOGENOM; CLU_547641_0_0_1; -.
DR   InParanoid; Q86K93; -.
DR   OMA; NFMFSDF; -.
DR   PhylomeDB; Q86K93; -.
DR   PRO; PR:Q86K93; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0000815; C:ESCRT III complex; ISS:UniProtKB.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0045324; P:late endosome to vacuole transport; ISS:UniProtKB.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..477
FT                   /note="Charged multivesicular body protein 7"
FT                   /id="PRO_0000328396"
FT   REGION          411..477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          252..280
FT                   /evidence="ECO:0000255"
FT   COILED          382..428
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        423..439
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   477 AA;  55552 MW;  3986982023A0AF12 CRC64;
     MNNDKEINSE KSKRAINHFS NKKEIKNSDR RGILFSKLPS QQLNPDRYDN LMTFWNNSLI
     DISKSCNILI FTPKLLSTYF TVENVSPIYL PLILNEMIKT KFIVKYEEYI KDYGWSKWVW
     TKMVVQPFQY YTGLSTPNTE TEKNVKFILP EMIKDKAEQL YQHQLKNMNS TTDNIISYIN
     LEKSIKDWYI TREELDLLLL VLFRDSKVLI LTNNKIKNIN NNNNGEDRIG IKFAFDGEKV
     QPIQETDFGI LKLQTTYETL KQQESKLLTD IEEISNTIKE SIRIKQKNHA LLQLKKKKLL
     ESILEKRATA STNIHEILFS IESAKSNQQI IESLCTGVST LKKVNQEISV DQVDSILDDY
     QDAITNQREI DDAMKSGFNS VESLSSADID EDQLEKELDQ MLQDHLTLEK EEKQKQKQIE
     KEKQQQQQPP TSQFNPNLPI PLKNEEDELL KELESLSVTS NPLPKQDENK QKTSELI