ID   CHMP7_XENLA             Reviewed;         422 AA.
AC   Q7T0X5;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Charged multivesicular body protein 7;
DE   AltName: Full=Chromatin-modifying protein 7;
GN   Name=chmp7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ESCRT-III-like protein required to recruit the ESCRT-III
CC       complex to the nuclear envelope during late anaphase. Together with
CC       SPAST, the ESCRT-III complex promotes nuclear envelope sealing and
CC       mitotic spindle disassembly during late anaphase. Plays a role in the
CC       endosomal sorting pathway. {ECO:0000250|UniProtKB:Q8WUX9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8WUX9}. Nucleus
CC       envelope {ECO:0000250|UniProtKB:Q8WUX9}. Note=Diffused localization,
CC       with some punctate distribution, especially in the perinuclear area.
CC       Localizes to the nucleus envelope during late anaphase.
CC       {ECO:0000250|UniProtKB:Q8WUX9}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; BC055997; AAH55997.1; -; mRNA.
DR   AlphaFoldDB; Q7T0X5; -.
DR   SMR; Q7T0X5; -.
DR   IntAct; Q7T0X5; 1.
DR   MaxQB; Q7T0X5; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0000815; C:ESCRT III complex; ISS:UniProtKB.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0010458; P:exit from mitosis; ISS:UniProtKB.
DR   GO; GO:0045324; P:late endosome to vacuole transport; ISS:UniProtKB.
DR   GO; GO:0031468; P:nuclear membrane reassembly; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..422
FT                   /note="Charged multivesicular body protein 7"
FT                   /id="PRO_0000211521"
FT   REGION          394..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          234..304
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   422 AA;  47710 MW;  5C2FFB04F89B4DD3 CRC64;
     MAPLSCNPPE WEDDERMSFL FSAFKRTRDV NTCDWDGKMK FWIPLILTHA RAQGLLSITL
     SQLENDFRRK GCAPMGLRTV IQEMIRQGTL RKETDFVSGV SSGWLSWGMR QLVIRPLRWT
     IGTMLGSQVG PDEPLVIPEV IKERAALVLQ RYQSSTFRSF PLLCEEEVHT LCAEICPNPS
     ALNLVLLQLQ GDKKICVLER AGQKLVKFVR VSVGQVEPIS ESDLGIYQLQ QGEKLLSERL
     QSAGEESNRL TEEARTYNRA GNKNQALRCL RKRKLVERRI TELQNKQDNI QGILERISAA
     ETDRKVVSAY QMGVSALKQA LKDVTLEKAE SIVDQIQEYC DLQDDLSQTL SSVTDADVDS
     DDLERELNEI LQNEEMIIDL PDVPSGPVII SPKRPTEWKM DQAAHSPADG SFLRSVPEPM
     LQ