CHODL_DANRE
ID CHODL_DANRE Reviewed; 296 AA.
AC Q568T5;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Chondrolectin;
DE Flags: Precursor;
GN Name=chodl; Synonyms=zgc:110088;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=22457492; DOI=10.1523/jneurosci.5179-11.2012;
RA Zhong Z., Ohnmacht J., Reimer M.M., Bach I., Becker T., Becker C.G.;
RT "Chondrolectin mediates growth cone interactions of motor axons with an
RT intermediate target.";
RL J. Neurosci. 32:4426-4439(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP POSSIBLE INVOLVEMENT IN SMA.
RX PubMed=24067532; DOI=10.1093/hmg/ddt477;
RA Sleigh J.N., Barreiro-Iglesias A., Oliver P.L., Biba A., Becker T.,
RA Davies K.E., Becker C.G., Talbot K.;
RT "Chondrolectin affects cell survival and neuronal outgrowth in in vitro and
RT in vivo models of spinal muscular atrophy.";
RL Hum. Mol. Genet. 23:855-869(2014).
CC -!- FUNCTION: Plays a role in the development of the nervous system such as
CC in neurite outgrowth and elongation. Involved in motor axon growth and
CC guidance. Required for correct interactions of motor axons with the
CC horizontal myoseptum. {ECO:0000269|PubMed:22457492}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in developing motor neurons.
CC {ECO:0000269|PubMed:22457492}.
CC -!- DEVELOPMENTAL STAGE: Expressed in primary motor neurons from early
CC stages of their differentiation (12 hpf) to at least 24 hpf.
CC {ECO:0000269|PubMed:22457492}.
CC -!- MISCELLANEOUS: Overexpression partially rescues the motor axon defects
CC upon Smn-depleted. {ECO:0000269|PubMed:24067532}.
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DR EMBL; JQ790525; AFI44996.1; -; mRNA.
DR EMBL; CT574587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC092727; AAH92727.1; -; mRNA.
DR EMBL; BC164239; AAI64239.1; -; mRNA.
DR RefSeq; NP_001017578.1; NM_001017578.2.
DR AlphaFoldDB; Q568T5; -.
DR SMR; Q568T5; -.
DR STRING; 7955.ENSDARP00000041334; -.
DR PaxDb; Q568T5; -.
DR Ensembl; ENSDART00000041335; ENSDARP00000041334; ENSDARG00000034528.
DR Ensembl; ENSDART00000185345; ENSDARP00000153783; ENSDARG00000109583.
DR Ensembl; ENSDART00000186280; ENSDARP00000151337; ENSDARG00000111154.
DR GeneID; 550240; -.
DR KEGG; dre:550240; -.
DR CTD; 140578; -.
DR ZFIN; ZDB-GENE-050417-36; chodl.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00390000001844; -.
DR HOGENOM; CLU_045492_1_0_1; -.
DR InParanoid; Q568T5; -.
DR OMA; VASATCC; -.
DR OrthoDB; 1005951at2759; -.
DR PhylomeDB; Q568T5; -.
DR TreeFam; TF330715; -.
DR PRO; PR:Q568T5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 24.
DR Bgee; ENSDARG00000034528; Expressed in spleen and 8 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IMP:ZFIN.
DR GO; GO:0008045; P:motor neuron axon guidance; IGI:ZFIN.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IGI:ZFIN.
DR GO; GO:0060386; P:synapse assembly involved in innervation; IMP:ZFIN.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Lectin; Membrane; Neurogenesis; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..296
FT /note="Chondrolectin"
FT /id="PRO_5009711686"
FT TOPO_DOM 21..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..296
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 38..187
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT REGION 197..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 296 AA; 32715 MW; 6AA80239B12E9AA4 CRC64;
MRATLRILCA LTFLVSCSRG ARVVSGQTVC QGNPEHPCYK IAYFKDVSSR VAFWEALQAC
EMDGGSLLSI ENTAEQKHIE HLLRELSVSS STGPASITDG DFWIGLTREE GDNAQEPGAF
ASCPNLYRWT DGSVSLFRNW YADEPSCGGE ACVVMYHQPT ALAGPGGPYL YQWNDDRCNM
KHNFICKYEP ESHLVKVQSD RPGGHDVDLS TEDKEDRRTP PTDEDESPRL IIAGPSSMLL
IYVIIPTIPL LLLILVASGT CCFQMLSKSK PRTKTSVNQS TLWISKTPKI DSGMEV
