位置:首页 > 蛋白库 > CHO_ECOLI
CHO_ECOLI
ID   CHO_ECOLI               Reviewed;         295 AA.
AC   P76213; Q2MB42;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Excinuclease cho;
DE            EC=3.1.25.-;
DE   AltName: Full=Endonuclease cho;
DE   AltName: Full=UvrC homolog protein;
GN   Name=cho; Synonyms=dinM, sosD, ydjQ; OrderedLocusNames=b1741, JW1730;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   REGULATION BY LEXA, AND INDUCTION.
RC   STRAIN=K12 / RW118;
RX   PubMed=10760155; DOI=10.1046/j.1365-2958.2000.01826.x;
RA   Fernandez De Henestrosa A.R., Ogi T., Aoyagi S., Chafin D., Hayes J.J.,
RA   Ohmori H., Woodgate R.;
RT   "Identification of additional genes belonging to the LexA regulon in
RT   Escherichia coli.";
RL   Mol. Microbiol. 35:1560-1572(2000).
RN   [4]
RP   FUNCTION.
RX   PubMed=11818552; DOI=10.1073/pnas.032584099;
RA   Moolenaar G.F., van Rossum-Fikkert S., van Kesteren M., Goosen N.;
RT   "Cho, a second endonuclease involved in Escherichia coli nucleotide
RT   excision repair.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:1467-1472(2002).
CC   -!- FUNCTION: Incises the DNA at the 3' side of a lesion during nucleotide
CC       excision repair. Incises the DNA farther away from the lesion than
CC       UvrC. Not able to incise the 5' site of a lesion. In vitro, the
CC       incision activity of Cho is UvrA and UvrB dependent. When a lesion
CC       remains because UvrC is not able to induce the 3' incision, Cho incises
CC       the DNA. Then UvrC makes the 5' incision. The combined action of Cho
CC       and UvrC broadens the substrate range of nucleotide excision repair.
CC       {ECO:0000269|PubMed:11818552}.
CC   -!- INTERACTION:
CC       P76213; P0A6F5: groEL; NbExp=3; IntAct=EBI-545155, EBI-543750;
CC   -!- INDUCTION: Repressed by LexA, induced by DNA damage.
CC       {ECO:0000269|PubMed:10760155}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U00096; AAC74811.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76514.1; -; Genomic_DNA.
DR   PIR; E64933; E64933.
DR   RefSeq; NP_416255.1; NC_000913.3.
DR   RefSeq; WP_000252397.1; NZ_SSZK01000001.1.
DR   AlphaFoldDB; P76213; -.
DR   SMR; P76213; -.
DR   BioGRID; 4261591; 124.
DR   BioGRID; 853244; 1.
DR   DIP; DIP-28067N; -.
DR   IntAct; P76213; 8.
DR   STRING; 511145.b1741; -.
DR   PaxDb; P76213; -.
DR   PRIDE; P76213; -.
DR   EnsemblBacteria; AAC74811; AAC74811; b1741.
DR   EnsemblBacteria; BAE76514; BAE76514; BAE76514.
DR   GeneID; 948996; -.
DR   KEGG; ecj:JW1730; -.
DR   KEGG; eco:b1741; -.
DR   PATRIC; fig|1411691.4.peg.515; -.
DR   EchoBASE; EB3749; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_054721_1_0_6; -.
DR   OMA; RVMSHFR; -.
DR   PhylomeDB; P76213; -.
DR   BioCyc; EcoCyc:G6937-MON; -.
DR   PRO; PR:P76213; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR   GO; GO:0004520; F:endodeoxyribonuclease activity; IDA:EcoCyc.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR   GO; GO:0033683; P:nucleotide-excision repair, DNA incision; IDA:EcoCyc.
DR   GO; GO:0009432; P:SOS response; IEP:EcoCyc.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
PE   1: Evidence at protein level;
KW   DNA damage; DNA excision; DNA repair; Excision nuclease; Hydrolase;
KW   Reference proteome; SOS response.
FT   CHAIN           1..295
FT                   /note="Excinuclease cho"
FT                   /id="PRO_0000138370"
FT   DOMAIN          33..108
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00977"
SQ   SEQUENCE   295 AA;  33739 MW;  DCEEADD895EF4327 CRC64;
     MVRRLTSPRL EFEAAAIYEY PEHLRSFLND LPTRPGVYLF HGESDTMPLY IGKSVNIRSR
     VLSHLRTPDE AAMLRQSRRI SWICTAGEIG ALLLEARLIK EQQPLFNKRL RRNRQLCALQ
     LNEKRVDVVY AKEVDFSRAP NLFGLFANRR AALQALQTIA DEQKLCYGLL GLEPLSRGRA
     CFRSALKRCA GACCGKESHE EHALRLRQSL ERLRVVCWPW QGAVALKEQH PEMTQYHIIQ
     NWLWLGAVNS LEEATTLIRT PAGFDHDGYK ILCKPLLSGN YEITELDPAN DQRAS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024