ID   CHO_SALTI               Reviewed;         293 AA.
AC   Q8Z6G5;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2002, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Excinuclease cho;
DE            EC=3.1.25.-;
DE   AltName: Full=Endonuclease cho;
DE   AltName: Full=UvrC homolog protein;
GN   Name=cho; OrderedLocusNames=STY1804, t1188;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Incises the DNA at the 3' side of a lesion during nucleotide
CC       excision repair. Incises the DNA farther away from the lesion than
CC       UvrC. Not able to incise the 5' site of a lesion. When a lesion remains
CC       because UvrC is not able to induce the 3' incision, Cho incises the
CC       DNA. Then UvrC makes the 5' incision. The combined action of Cho and
CC       UvrC broadens the substrate range of nucleotide excision repair (By
CC       similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO68844.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAD02045.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL513382; CAD02045.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014613; AAO68844.1; ALT_INIT; Genomic_DNA.
DR   PIR; AD0709; AD0709.
DR   RefSeq; NP_456203.1; NC_003198.1.
DR   RefSeq; WP_001518228.1; NZ_QGEV01000049.1.
DR   AlphaFoldDB; Q8Z6G5; -.
DR   SMR; Q8Z6G5; -.
DR   STRING; 220341.16502882; -.
DR   EnsemblBacteria; AAO68844; AAO68844; t1188.
DR   KEGG; stt:t1188; -.
DR   KEGG; sty:STY1804; -.
DR   PATRIC; fig|220341.7.peg.1817; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_054721_1_0_6; -.
DR   OMA; RVMSHFR; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA excision; DNA repair; Excision nuclease; Hydrolase;
KW   SOS response.
FT   CHAIN           1..293
FT                   /note="Excinuclease cho"
FT                   /id="PRO_0000138373"
FT   DOMAIN          33..108
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00977"
SQ   SEQUENCE   293 AA;  33333 MW;  4985E05E856F7EE0 CRC64;
     MVRRQSAPRL EFEAAAIYEY PEHLRPFLSE APALPGVYIF HSESDTLPLY IGKSVNIRSR
     VLSHLRTPDE AAMLRQARRI SWICTAGEMG ALLLEARLIK EQQPLFNKRL RRNRQLCSLQ
     LSEQKIEVVS ARSVDFSHEP NLFGLFANRR AALQSLQNLA DEQKLCYGLL GLEPVSRGRA
     CFRFALKRCA GACCGQETPQ AHFLRLQASL ERLRVVCWPW KGAIALKESR PQMTQFHIIN
     NWLWLGAVPS LDEAATLVRT PAGFDQDGYK ILCKPLMSGQ YEIIELHTDC RQS