CHP2_SCHPO
ID CHP2_SCHPO Reviewed; 380 AA.
AC O42934;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Chromo domain-containing protein 2;
GN Name=chp2; ORFNames=SPBC16C6.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=10835380; DOI=10.1093/genetics/155.2.551;
RA Thon G., Verhein-Hansen J.;
RT "Four chromo-domain proteins of Schizosaccharomyces pombe differentially
RT repress transcription at various chromosomal locations.";
RL Genetics 155:551-568(2000).
CC -!- FUNCTION: Component of the kinetochore which plays a role in
CC stabilizing microtubules and so allowing accurate chromosome
CC segregation. {ECO:0000269|PubMed:10835380}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; CU329671; CAA16917.1; -; Genomic_DNA.
DR PIR; T39561; T39561.
DR RefSeq; NP_596808.1; NM_001023829.2.
DR PDB; 6FTO; X-ray; 1.60 A; A/B=315-380.
DR PDBsum; 6FTO; -.
DR AlphaFoldDB; O42934; -.
DR SMR; O42934; -.
DR BioGRID; 276585; 13.
DR STRING; 4896.SPBC16C6.10.1; -.
DR iPTMnet; O42934; -.
DR PaxDb; O42934; -.
DR PRIDE; O42934; -.
DR EnsemblFungi; SPBC16C6.10.1; SPBC16C6.10.1:pep; SPBC16C6.10.
DR GeneID; 2540047; -.
DR KEGG; spo:SPBC16C6.10; -.
DR PomBase; SPBC16C6.10; chp2.
DR VEuPathDB; FungiDB:SPBC16C6.10; -.
DR eggNOG; KOG1911; Eukaryota.
DR HOGENOM; CLU_727924_0_0_1; -.
DR InParanoid; O42934; -.
DR OMA; GMEENSW; -.
DR PhylomeDB; O42934; -.
DR Reactome; R-SPO-73772; RNA Polymerase I Promoter Escape.
DR PRO; PR:O42934; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0099115; C:chromosome, subtelomeric region; TAS:PomBase.
DR GO; GO:0031934; C:mating-type region heterochromatin; TAS:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005721; C:pericentric heterochromatin; IDA:PomBase.
DR GO; GO:0110129; C:SHREC2 complex; IDA:PomBase.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042393; F:histone binding; EXP:PomBase.
DR GO; GO:0035064; F:methylated histone binding; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IMP:PomBase.
DR GO; GO:0031048; P:heterochromatin assembly by small RNA; IMP:PomBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0031508; P:pericentric heterochromatin assembly; IMP:PomBase.
DR GO; GO:0000183; P:rDNA heterochromatin assembly; IMP:PomBase.
DR GO; GO:0030466; P:silent mating-type cassette heterochromatin assembly; IMP:PomBase.
DR GO; GO:0031509; P:subtelomeric heterochromatin assembly; IMP:PomBase.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR008251; Chromo_shadow_dom.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF01393; Chromo_shadow; 1.
DR SMART; SM00298; CHROMO; 1.
DR SMART; SM00300; ChSh; 1.
DR SUPFAM; SSF54160; SSF54160; 2.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..380
FT /note="Chromo domain-containing protein 2"
FT /id="PRO_0000080239"
FT DOMAIN 176..238
FT /note="Chromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00053"
FT REGION 14..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT TURN 325..327
FT /evidence="ECO:0007829|PDB:6FTO"
FT STRAND 328..336
FT /evidence="ECO:0007829|PDB:6FTO"
FT STRAND 342..348
FT /evidence="ECO:0007829|PDB:6FTO"
FT STRAND 353..357
FT /evidence="ECO:0007829|PDB:6FTO"
FT HELIX 358..364
FT /evidence="ECO:0007829|PDB:6FTO"
FT HELIX 366..374
FT /evidence="ECO:0007829|PDB:6FTO"
FT STRAND 377..379
FT /evidence="ECO:0007829|PDB:6FTO"
SQ SEQUENCE 380 AA; 42955 MW; A2D96BD5987807C4 CRC64;
MVKSADLDLM NSIISESDEN FSPPPFTVEE AENSINNKSS TASLESPQNG SWHPSLYGLS
VPEKTHIQNS LDLYSHGNSG SQKTHNVSFS CEIRKVKSSK LSPISNMEDS EDKKEEDESS
SYKNEFKSSS SASVSSNFEK TSGSDDHNSQ SPVPLNEGFE YIASSGSEDK NSDEEFAVEM
ILDSRMKKDG SGFQYYLKWE GYDDPSDNTW NDEEDCAGCL ELIDAYWESR GGKPDLSSLI
RLTRSRARSS NEASYVEKDE SSNSDDSISY KRRRSRNAAN RITDYVDSDL SESSMKEKQS
KIEKYMKSDK SSKNFKPPFQ KKSWEDLVDC VKTVQQLDNG KLIAKIKWKN GYVSTHDNII
IHQKCPLKII EYYEAHIKFT
