CHR1_SCHPO
ID CHR1_SCHPO Reviewed; 456 AA.
AC O59732;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Chitin synthase regulatory factor 1;
DE AltName: Full=Chs four homolog 4;
GN Name=chr1; Synonyms=cfh4; ORFNames=SPBC3E7.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION, AND POSSIBLE FUNCTION.
RX PubMed=15449309; DOI=10.1002/yea.1145;
RA Matsuo Y., Matsuura Y., Tanaka K., Matsuda H., Kawamukai M.;
RT "Chr4, a Schizosaccharomyces pombe homologue of the Saccharomyces
RT cerevisiae Chs4p/Skt5p protein, is related to septum formation and is
RT required for the proper localization of Chs2.";
RL Yeast 21:1005-1019(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227 AND SER-230, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Involved in chitin biosynthesis. {ECO:0000305}.
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DR EMBL; CU329671; CAA19015.1; -; Genomic_DNA.
DR PIR; T40386; T40386.
DR RefSeq; NP_596099.1; NM_001022015.2.
DR AlphaFoldDB; O59732; -.
DR SMR; O59732; -.
DR BioGRID; 276796; 5.
DR STRING; 4896.SPBC3E7.12c.1; -.
DR iPTMnet; O59732; -.
DR MaxQB; O59732; -.
DR PaxDb; O59732; -.
DR PRIDE; O59732; -.
DR EnsemblFungi; SPBC3E7.12c.1; SPBC3E7.12c.1:pep; SPBC3E7.12c.
DR GeneID; 2540265; -.
DR KEGG; spo:SPBC3E7.12c; -.
DR PomBase; SPBC3E7.12c; -.
DR VEuPathDB; FungiDB:SPBC3E7.12c; -.
DR eggNOG; KOG1550; Eukaryota.
DR HOGENOM; CLU_642753_0_0_1; -.
DR InParanoid; O59732; -.
DR OMA; AFEYAHR; -.
DR PRO; PR:O59732; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0051278; P:fungal-type cell wall polysaccharide biosynthetic process; TAS:PomBase.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF08238; Sel1; 3.
DR SMART; SM00671; SEL1; 4.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..456
FT /note="Chitin synthase regulatory factor 1"
FT /id="PRO_0000076205"
FT REPEAT 293..327
FT /note="Sel1-like 1"
FT REPEAT 328..364
FT /note="Sel1-like 2"
FT REPEAT 365..402
FT /note="Sel1-like 3"
FT REPEAT 403..438
FT /note="Sel1-like 4"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 227
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 230
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 456 AA; 49568 MW; E8B423B3BB995C48 CRC64;
MPASTSIPET PSKLPDALLV NSDPASKVDN VSVKIEQESP LALEGSPLPT VSDVLPETNN
AHEEVSSSSW SLSSSDSIMS YDSLSDDVSV LSFLDCPLTT FETAPSIASF SNSAADVSSH
SRSSSSWSAK LSRFTKHASK PSLSSNSSDS SFSKSGSESN ALSSRGSFEL EPHGIHRHVS
RAKRLLSKFY SKFHHKKEDS SFDPLAPLVF APNTSRVLRV TNEANASAIS LEKATSLSSQ
EQPGSEIKKE LSLYDHEFDQ ILDLAIKAKK DGNLENAIEF LEYIMPEVAS QQNFVPYELA
ELYKQRGTSQ DLKSILPLYM LAASLGHDRS SFLVGEAFFY GTYGARENKL RALQYYHLAN
DKGNADAMLA LCKLYLRGLP GHIFPSSRRA FEYAHRAAML GHAPACYVLG KFYETGVGCV
KDLAKSEAGF RAGLINDSPI TDADALQIAS TLVLLQ
