CHR2_SCHPO
ID CHR2_SCHPO Reviewed; 512 AA.
AC O94486;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Chitin synthase regulatory factor 2;
DE AltName: Full=Chs four homolog 2;
DE Flags: Precursor;
GN Name=chr2; Synonyms=cfh2; ORFNames=SPCC417.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=14655046; DOI=10.1007/s00438-003-0938-8;
RA Miki F., Kurabayashi A., Tange Y., Okazaki K., Shimanuki M., Niwa O.;
RT "Two-hybrid search for proteins that interact with Sad1 and Kms1, two
RT membrane-bound components of the spindle pole body in fission yeast.";
RL Mol. Genet. Genomics 270:449-461(2004).
RN [3]
RP IDENTIFICATION, AND POSSIBLE FUNCTION.
RX PubMed=15449309; DOI=10.1002/yea.1145;
RA Matsuo Y., Matsuura Y., Tanaka K., Matsuda H., Kawamukai M.;
RT "Chr4, a Schizosaccharomyces pombe homologue of the Saccharomyces
RT cerevisiae Chs4p/Skt5p protein, is related to septum formation and is
RT required for the proper localization of Chs2.";
RL Yeast 21:1005-1019(2004).
CC -!- FUNCTION: Involved in chitin biosynthesis. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:14655046}; Lipid-
CC anchor {ECO:0000269|PubMed:14655046}.
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DR EMBL; CU329672; CAA22651.1; -; Genomic_DNA.
DR PIR; T41340; T41340.
DR RefSeq; NP_588282.1; NM_001023272.2.
DR AlphaFoldDB; O94486; -.
DR SMR; O94486; -.
DR BioGRID; 276056; 1.
DR IntAct; O94486; 1.
DR STRING; 4896.SPCC417.05c.1; -.
DR iPTMnet; O94486; -.
DR MaxQB; O94486; -.
DR PaxDb; O94486; -.
DR PRIDE; O94486; -.
DR EnsemblFungi; SPCC417.05c.1; SPCC417.05c.1:pep; SPCC417.05c.
DR GeneID; 2539493; -.
DR KEGG; spo:SPCC417.05c; -.
DR PomBase; SPCC417.05c; -.
DR VEuPathDB; FungiDB:SPCC417.05c; -.
DR eggNOG; KOG1550; Eukaryota.
DR HOGENOM; CLU_532270_0_0_1; -.
DR InParanoid; O94486; -.
DR PhylomeDB; O94486; -.
DR PRO; PR:O94486; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF08238; Sel1; 6.
DR SMART; SM00671; SEL1; 6.
PE 3: Inferred from homology;
KW Lipoprotein; Membrane; Methylation; Prenylation; Reference proteome;
KW Repeat.
FT CHAIN 1..509
FT /note="Chitin synthase regulatory factor 2"
FT /id="PRO_0000089573"
FT PROPEP 510..512
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000396745"
FT REPEAT 224..260
FT /note="Sel1-like 1"
FT REPEAT 261..296
FT /note="Sel1-like 2"
FT REPEAT 297..333
FT /note="Sel1-like 3"
FT REPEAT 337..377
FT /note="Sel1-like 4"
FT REPEAT 378..414
FT /note="Sel1-like 5"
FT REPEAT 415..452
FT /note="Sel1-like 6"
FT MOD_RES 509
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 509
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 512 AA; 58421 MW; 113BE672A8CC87DF CRC64;
MLVSNGGTGS AHEWDRTTID YDIEPSSDTH AIEISSNDDY LHPLAQFKKS EEFDEVPTNT
LIHEVPSFSD SASNIQSQRN LSPFKELEIV SKKKSEQTFS SAVDFSAINV KNLNLKSGLF
DPEPPSYDPD YAFNQRSLQS DPGSDEMFRN FKKSISLEEL KSSYKLASAE MCEPETRLSF
LQLALQAEKS SSRRNREYVA RKKEEAFDYL TSFVSQGNSF FGYSEALYLL AVCYGTGALR
TEINEKEAYR LYKMAADLNH VQAAYRVAIC LQMGFGVTQN TEEAIHYFFR AASGQHVGAM
HRMALIYFRG LMSVKRDPVK AMYYLNLGAL EADHEFPQAL YDLAELYEHG SSYLDGLLEL
SPRKAFVLYH IAAKYGLKDA QLRVARCFEL GQLECDINLV RSFVWYRRLA RKRNPEAMWK
LSQFYLNGVD DVIYPNPELA NEWAKAAAYK NHHLASTFVQ DVGKEDVFEK TSITISNEER
KSRNSESLPK KKKRLSMLSF KRSKNRESCI IS
