CHR4_SCHPO
ID CHR4_SCHPO Reviewed; 633 AA.
AC O94614; Q7LKX7; Q9Y7Z0;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 4.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Chitin synthase regulatory factor 4;
DE AltName: Full=Chs four homolog 3;
GN Name=chr4; Synonyms=cfh3; ORFNames=SPBC1289.01c, SPBC1539.11c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15449309; DOI=10.1002/yea.1145;
RA Matsuo Y., Matsuura Y., Tanaka K., Matsuda H., Kawamukai M.;
RT "Chr4, a Schizosaccharomyces pombe homologue of the Saccharomyces
RT cerevisiae Chs4p/Skt5p protein, is related to septum formation and is
RT required for the proper localization of Chs2.";
RL Yeast 21:1005-1019(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Involved in septum formation. Required for the proper
CC localization of chs2 at the septum. {ECO:0000269|PubMed:15449309}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15449309}.
CC Note=Localizes to the cell tips and septum during vegetative growth.
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DR EMBL; CU329671; CAB51343.1; -; Genomic_DNA.
DR PIR; T39352; T39352.
DR RefSeq; NP_596825.2; NM_001023845.3.
DR AlphaFoldDB; O94614; -.
DR SMR; O94614; -.
DR BioGRID; 276269; 6.
DR STRING; 4896.SPBC1289.01c.1; -.
DR iPTMnet; O94614; -.
DR MaxQB; O94614; -.
DR PaxDb; O94614; -.
DR PRIDE; O94614; -.
DR EnsemblFungi; SPBC1289.01c.1; SPBC1289.01c.1:pep; SPBC1289.01c.
DR GeneID; 2539716; -.
DR KEGG; spo:SPBC1289.01c; -.
DR PomBase; SPBC1289.01c; chr4.
DR VEuPathDB; FungiDB:SPBC1289.01c; -.
DR eggNOG; KOG1550; Eukaryota.
DR HOGENOM; CLU_425233_0_0_1; -.
DR InParanoid; O94614; -.
DR OMA; YGIGDMI; -.
DR PhylomeDB; O94614; -.
DR PRO; PR:O94614; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000148; C:1,3-beta-D-glucan synthase complex; IPI:PomBase.
DR GO; GO:0051285; C:cell cortex of cell tip; IDA:PomBase.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0051286; C:cell tip; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000935; C:division septum; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0070880; P:fungal-type cell wall beta-glucan biosynthetic process; IMP:PomBase.
DR GO; GO:0140278; P:mitotic division septum assembly; IMP:PomBase.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF08238; Sel1; 4.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00671; SEL1; 5.
DR SMART; SM00028; TPR; 2.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cytoplasm; Phosphoprotein; Reference proteome;
KW Repeat; Septation.
FT CHAIN 1..633
FT /note="Chitin synthase regulatory factor 4"
FT /id="PRO_0000076207"
FT REPEAT 278..314
FT /note="Sel1-like 1"
FT REPEAT 315..346
FT /note="Sel1-like 2"
FT REPEAT 438..474
FT /note="Sel1-like 3"
FT REPEAT 475..511
FT /note="Sel1-like 4"
FT REPEAT 512..543
FT /note="Sel1-like 5"
FT REGION 121..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 148
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 633 AA; 70016 MW; 9DC64034E43795CE CRC64;
MDSASSMRNR SPLGVPEFSY SSQSVNNIRG IKSRNRSSIG HSITDPQVAS RINAFYLSNV
QSSIPFETDA IGPAYGIGDM IAPEMNDTQS LSASVTNMKK ENFYSRPNVS SSSILLTIKR
ATSSQETKRD RPLPNIRNSA PSATRSHSTP CVAPGYLRTS NEAADVVFPH EEAHFSNHNP
KPNNGSPLQK QVVADLPFPL PVSDEEQLDW IRANEDLVHS QDIDEALEWA EYVLRFTQSH
LPYLQTYESE NLHEINYLES MCENALYKIR EFSELENAKA MYFDAYVYET GAFDVESDIQ
RAWDLYSSSA NLGYTRSLYR LGVLLEDQGN LEEAVEYFEK GVSENDSACC WRLSLLILEG
MLDGVGEYAH RHASGLELLE RSADTADADV PSGLYSHALV NLHEHPGLVD LGSENIRVPI
DEATALKSFA KAAFLGHSSA QLRMGAVYEF GKYGCPVVPR YSLFYYSAAA KRGETEADLA
VAKWYLNGSD GIPVDEDLAF MHAERASMAG NANAQFLMGY LFDTRGNTEQ ATYWYNEAAK
AGHSEAIERL ALLENQIQEP EPENITSSQY PNQDVIKEIP VTASETSPPH APAVSSTPVT
SAPPVSQTKV TKVSVPKKTS KKFLIKHNKC IIS
