CHR9_ARATH
ID CHR9_ARATH Reviewed; 862 AA.
AC F4I2H2; Q9ZW97;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Switch 2 {ECO:0000312|EMBL:AEE27606.1};
DE EC=3.6.4.-;
DE AltName: Full=Protein CHROMATIN REMODELING 9 {ECO:0000303|PubMed:16547115};
DE Short=AtCHR9;
GN Name=SWI2 {ECO:0000312|EMBL:AEE27606.1};
GN Synonyms=CHR9 {ECO:0000303|PubMed:16547115};
GN OrderedLocusNames=At1g03750 {ECO:0000312|Araport:AT1G03750};
GN ORFNames=F11M21.32 {ECO:0000312|EMBL:AAD10693.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16547115; DOI=10.1534/genetics.105.051664;
RA Shaked H., Avivi-Ragolsky N., Levy A.A.;
RT "Involvement of the Arabidopsis SWI2/SNF2 chromatin remodeling gene family
RT in DNA damage response and recombination.";
RL Genetics 173:985-994(2006).
RN [4]
RP GENE FAMILY.
RX PubMed=24265739; DOI=10.1371/journal.pone.0078982;
RA Xu R., Zhang S., Huang J., Zheng C.;
RT "Genome-wide comparative in silico analysis of the RNA helicase gene family
RT in Zea mays and Glycine max: a comparison with Arabidopsis and Oryza
RT sativa.";
RL PLoS ONE 8:E78982-E78982(2013).
CC -!- FUNCTION: May be involved in early DNA damage response (By similarity).
CC Probable chromatin remodeling factor. {ECO:0000250|UniProtKB:Q5T890,
CC ECO:0000303|PubMed:16547115}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD10693.1; Type=Erroneous gene model prediction;
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DR EMBL; AC003027; AAD10693.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27606.1; -; Genomic_DNA.
DR PIR; H86167; H86167.
DR RefSeq; NP_171871.2; NM_100254.4.
DR AlphaFoldDB; F4I2H2; -.
DR SMR; F4I2H2; -.
DR BioGRID; 24652; 2.
DR IntAct; F4I2H2; 2.
DR STRING; 3702.AT1G03750.1; -.
DR iPTMnet; F4I2H2; -.
DR PaxDb; F4I2H2; -.
DR PRIDE; F4I2H2; -.
DR ProteomicsDB; 246787; -.
DR EnsemblPlants; AT1G03750.1; AT1G03750.1; AT1G03750.
DR GeneID; 839417; -.
DR Gramene; AT1G03750.1; AT1G03750.1; AT1G03750.
DR KEGG; ath:AT1G03750; -.
DR Araport; AT1G03750; -.
DR TAIR; locus:2024198; AT1G03750.
DR eggNOG; KOG0387; Eukaryota.
DR HOGENOM; CLU_000315_23_1_1; -.
DR InParanoid; F4I2H2; -.
DR OMA; VYTHRNE; -.
DR OrthoDB; 372069at2759; -.
DR PRO; PR:F4I2H2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4I2H2; baseline and differential.
DR Genevisible; F4I2H2; AT.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.10810; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; DNA damage; DNA repair; DNA-binding; Helicase;
KW Hydrolase; Nucleotide-binding; Reference proteome.
FT CHAIN 1..862
FT /note="Switch 2"
FT /id="PRO_0000430855"
FT DOMAIN 151..323
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 532..685
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 13..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 274..294
FT /evidence="ECO:0000255"
FT MOTIF 274..277
FT /note="DEAH box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT COMPBIAS 58..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 164..171
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 862 AA; 98486 MW; 9537F3E6E130CCE1 CRC64;
MSLLHTFKET LKPCGSFPSS SSLRVSSTQE LEPSRKPPKS SLSQQLLRLD DSYFLPSKHE
SKISKTQVED FDHNEDDHKR NIKFDEEEVD EDDERSIEFG RPGLSRAEFD YSGPYEPLML
SSIGEIPIIH VPASINCRLL EHQREGVKFM YNLYKNNHGG ILGDDMGLGK TIQTIAFLAA
VYGKDGDAGE SCLLESDKGP VLIICPSSII HNWESEFSRW ASFFKVSVYH GSNRDMILEK
LKARGVEVLV TSFDTFRIQG PVLSGINWEI VIADEAHRLK NEKSKLYEAC LEIKTKKRIG
LTGTVMQNKI SELFNLFEWV APGSLGTREH FRDFYDEPLK LGQRATAPER FVQIADKRKQ
HLGSLLRKYM LRRTKEETIG HLMMGKEDNV VFCQMSQLQR RVYQRMIQLP EIQCLVNKDN
PCACGSPLKQ SECCRRIVPD GTIWSYLHRD NHDGCDSCPF CLVLPCLMKL QQISNHLELI
KPNPKDEPEK QKKDAEFVST VFGTDIDLLG GISASKSFMD LSDVKHCGKM RALEKLMASW
ISKGDKILLF SYSVRMLDIL EKFLIRKGYS FARLDGSTPT NLRQSLVDDF NASPSKQVFL
ISTKAGGLGL NLVSANRVVI FDPNWNPSHD LQAQDRSFRY GQKRHVVVFR LLSAGSLEEL
VYTRQVYKQQ LSNIAVAGKM ETRYFEGVQD CKEFQGELFG ISNLFRDLSD KLFTSDIVEL
HRDSNIDENK KRSLLETGVS EDEKEEEVMC SYKPEMEKPI LKDLGIVYAH RNEDIINIGE
TTTSTSQRLN GDGNSADRKK KKRKGCSEEE DMSSSNREQK REKYKMLAEF KGMEILEFSR
WVLSASPFDR EKLLQDFLER VK
