ID   CHRB1_CUPMC             Reviewed;         324 AA.
AC   P17552; Q1L9W4; Q5NV01; Q93JN1;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Protein ChrB {ECO:0000305};
GN   Name=chrB1 {ECO:0000312|EMBL:CAC42410.1};
GN   Synonyms=chrB {ECO:0000303|PubMed:2180932};
GN   OrderedLocusNames=Rmet_6203 {ECO:0000312|EMBL:ABF13062.1};
GN   ORFNames=RMe0089 {ECO:0000312|EMBL:CAI30233.1};
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS   CH34) (Ralstonia metallidurans).
OG   Plasmid pMOL28.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=2180932; DOI=10.1016/s0021-9258(19)39411-6;
RA   Nies A., Nies D.H., Silver S.;
RT   "Nucleotide sequence and expression of a plasmid-encoded chromate
RT   resistance determinant from Alcaligenes eutrophus.";
RL   J. Biol. Chem. 265:5648-5653(1990).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS, AND INDUCTION.
RX   PubMed=12471500; DOI=10.1007/s00203-002-0492-5;
RA   Juhnke S., Peitzsch N., Huebener N., Grosse C., Nies D.H.;
RT   "New genes involved in chromate resistance in Ralstonia metallidurans
RT   strain CH34.";
RL   Arch. Microbiol. 179:15-25(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   van der Lelie D., Monchy S., Taghavi S., McCorkle S., Dunn J.,
RA   Benotmane M., Vallaeys T., Lapidus A., Mergeay M.;
RT   "Sequence and features of the Ralstonia metallidurans CH34 heavy metal
RT   plasmids pMOL28 and pMOL30.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34;
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA   Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA   Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT   master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
CC   -!- FUNCTION: Together with ChrA1, this protein reduces chromate
CC       accumulation and is essential for chromate resistance, possibly as a
CC       regulatory protein. {ECO:0000269|PubMed:2180932}.
CC   -!- INDUCTION: By chromate; induction increases when cells are grown in the
CC       presence of high sulfate concentrations (3 mM SO4(2-)).
CC       {ECO:0000269|PubMed:12471500}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAI30233.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ313327; CAC42410.1; -; Genomic_DNA.
DR   EMBL; X90708; CAI30233.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP000355; ABF13062.1; -; Genomic_DNA.
DR   PIR; A35177; A35177.
DR   RefSeq; WP_011514878.1; NC_007972.2.
DR   RefSeq; YP_161711.1; NC_006525.1.
DR   AlphaFoldDB; P17552; -.
DR   SMR; P17552; -.
DR   EnsemblBacteria; ABF13062; ABF13062; Rmet_6203.
DR   GeneID; 60825780; -.
DR   KEGG; rme:Rmet_6203; -.
DR   HOGENOM; CLU_079058_0_0_4; -.
DR   OMA; FTHIGDR; -.
DR   OrthoDB; 1108707at2; -.
DR   Proteomes; UP000002429; Plasmid pMOL28.
DR   GO; GO:0046687; P:response to chromate; IEA:UniProtKB-KW.
DR   InterPro; IPR018634; Chromate_resist.
DR   Pfam; PF09828; Chrome_Resist; 1.
PE   2: Evidence at transcript level;
KW   Chromate resistance; Plasmid; Reference proteome.
FT   CHAIN           1..324
FT                   /note="Protein ChrB"
FT                   /id="PRO_0000089655"
SQ   SEQUENCE   324 AA;  35993 MW;  F3B6922FD73A4675 CRC64;
     MNALPSSPET AWLLLVVSLP TSASTARMRF WRGIKALGAT ALRDGAYLLP NLPGLRAPLQ
     TLATDAASED GKVWMLSVQA ADDQQEAEYR ALFDRSTEYA EWMVELSSAR STLSDSDEAE
     LLRVARRHGR GIDAIRKVDF FPNEASARAE LQWRDFNAAI DILLSPGEPH GVAGNIPRRD
     PTQYQGRQWA TRQHLWVDRV ACAWLIRRFI DPHATFLWLE DVRQCPDDAL GFDFDGATFT
     HIGDRVSFEV LLASFGLDED KGLARLGQMI HVLDVGGTPV AEASGFEAVL AGARERLPND
     DALLDEVGYV LDSLYTHFSS PRKR