ID   CHRB_DROPS              Reviewed;         289 AA.
AC   Q2LZ58;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein charybde;
GN   Name=chrb; ORFNames=GA20420;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2]
RP   IDENTIFICATION, AND INDUCTION.
RX   PubMed=16423342; DOI=10.1016/j.ydbio.2005.12.014;
RA   Scuderi A., Simin K., Kazuko S.G., Metherall J.E., Letsou A.;
RT   "scylla and charybde, homologues of the human apoptotic gene RTP801, are
RT   required for head involution in Drosophila.";
RL   Dev. Biol. 291:110-122(2006).
CC   -!- FUNCTION: Inhibits cell growth by regulating the Tor pathway upstream
CC       of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as cell death
CC       activator during head development (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By homeobox transcription factors.
CC       {ECO:0000305|PubMed:16423342}.
CC   -!- SIMILARITY: Belongs to the DDIT4 family. {ECO:0000305}.
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DR   EMBL; CH379069; EAL29651.1; -; Genomic_DNA.
DR   RefSeq; XP_001353915.1; XM_001353879.3.
DR   AlphaFoldDB; Q2LZ58; -.
DR   SMR; Q2LZ58; -.
DR   STRING; 7237.FBpp0274169; -.
DR   EnsemblMetazoa; FBtr0275731; FBpp0274169; FBgn0080415.
DR   GeneID; 4813232; -.
DR   KEGG; dpo:Dpse_GA20420; -.
DR   eggNOG; ENOG502R3EE; Eukaryota.
DR   HOGENOM; CLU_074668_0_0_1; -.
DR   InParanoid; Q2LZ58; -.
DR   OMA; IKDWQAA; -.
DR   PhylomeDB; Q2LZ58; -.
DR   ChiTaRS; chrb; fly.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0080415; Expressed in insect adult head and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR   GO; GO:0008258; P:head involution; ISS:UniProtKB.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:InterPro.
DR   GO; GO:0032006; P:regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0006979; P:response to oxidative stress; ISS:UniProtKB.
DR   Gene3D; 3.90.470.40; -; 1.
DR   InterPro; IPR012918; RTP801-like.
DR   InterPro; IPR038281; RTP801-like_C_sf.
DR   PANTHER; PTHR12478; PTHR12478; 1.
DR   Pfam; PF07809; RTP801_C; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Developmental protein; Reference proteome.
FT   CHAIN           1..289
FT                   /note="Protein charybde"
FT                   /id="PRO_0000307210"
FT   REGION          119..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   289 AA;  31335 MW;  0BDCE88ADEC5FB08 CRC64;
     MKMEVLSVQN HIQGKFGVNK IKDWPSSGVA STAPHPLEEE EENAVDVNAA LDADVVDGHP
     ASVLHMRQHQ ALNTRSTVPM APPVAGSGKQ SAVAASFDVV NGSSAAYHHA YMTNVLASTA
     HHPGHGHGPG PSPMPASPLQ STAGARFGAA DNMDDVSASA VRDLSQQLQF QLRDAKQRHL
     ACTEVNLPAD LTERIAAEII RMSDREPCGE RACTLFIEFE SEPNNVRRIA SFKVDPDTVS
     IFELYLTLKQ DKSGWTSLLP QFIKNLTRSN TINISPDFTL TKNKLYSSE