CHRD_HUMAN
ID CHRD_HUMAN Reviewed; 955 AA.
AC Q9H2X0; O95254; Q2M1I8; Q6UW83; Q9H2D3; Q9H2W8; Q9H2W9; Q9P0Z2; Q9P0Z3;
AC Q9P0Z4; Q9P0Z5;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Chordin;
DE Flags: Precursor;
GN Name=CHRD; ORFNames=UNQ217/PRO243;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), AND VARIANT LEU-630.
RX PubMed=11472837; DOI=10.1016/s0925-4773(01)00423-3;
RA Millet C., Lemaire P., Orsetti B., Guglielmi P., Francois V.;
RT "The human chordin gene encodes several differentially expressed spliced
RT variants with distinct BMP opposing activities.";
RL Mech. Dev. 106:85-96(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 115-955 (ISOFORM 5), AND VARIANT LEU-630.
RX PubMed=9782094; DOI=10.1006/geno.1998.5474;
RA Pappano W.N., Scott I.C., Clark T.G., Eddy R.L., Shows T.B.,
RA Greenspan D.S.;
RT "Coding sequence and expression patterns of mouse chordin and mapping of
RT the cognate mouse chrd and human CHRD genes.";
RL Genomics 52:236-239(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 51-125; 705-762; 784-850 AND 872-932.
RX PubMed=10648240; DOI=10.1242/dev.127.4.821;
RA Larrain J., Bachiller D., Lu B., Agius E., Piccolo S., De Robertis E.M.;
RT "BMP-binding modules in chordin: a model for signalling regulation in the
RT extracellular space.";
RL Development 127:821-830(2000).
RN [6]
RP SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
RX PubMed=14759258; DOI=10.1186/gb-2004-5-2-r8;
RA Hillman R.T., Green R.E., Brenner S.E.;
RT "An unappreciated role for RNA surveillance.";
RL Genome Biol. 5:R8.1-R8.16(2004).
CC -!- FUNCTION: Dorsalizing factor. Key developmental protein that dorsalizes
CC early vertebrate embryonic tissues by binding to ventralizing TGF-beta
CC family bone morphogenetic proteins (BMPs) and sequestering them in
CC latent complexes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TWSG1 and/or BMP4. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9H2X0; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-947551, EBI-10173507;
CC Q9H2X0; P13497: BMP1; NbExp=2; IntAct=EBI-947551, EBI-489827;
CC Q9H2X0; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-947551, EBI-744545;
CC Q9H2X0; Q6WN34-2: CHRDL2; NbExp=3; IntAct=EBI-947551, EBI-12593838;
CC Q9H2X0; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-947551, EBI-3867333;
CC Q9H2X0; P15976-2: GATA1; NbExp=3; IntAct=EBI-947551, EBI-9090198;
CC Q9H2X0; P49639: HOXA1; NbExp=4; IntAct=EBI-947551, EBI-740785;
CC Q9H2X0; Q0VD86: INCA1; NbExp=3; IntAct=EBI-947551, EBI-6509505;
CC Q9H2X0; O76011: KRT34; NbExp=3; IntAct=EBI-947551, EBI-1047093;
CC Q9H2X0; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-947551, EBI-11959885;
CC Q9H2X0; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-947551, EBI-11749135;
CC Q9H2X0; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-947551, EBI-10172150;
CC Q9H2X0; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-947551, EBI-10172290;
CC Q9H2X0; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-947551, EBI-10171774;
CC Q9H2X0; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-947551, EBI-10172052;
CC Q9H2X0; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-947551, EBI-10210845;
CC Q9H2X0; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-947551, EBI-10176379;
CC Q9H2X0; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-947551, EBI-11953334;
CC Q9H2X0; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-947551, EBI-12196745;
CC Q9H2X0; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-947551, EBI-1048945;
CC Q9H2X0; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-947551, EBI-739863;
CC Q9H2X0; Q9BYR5: KRTAP4-2; NbExp=6; IntAct=EBI-947551, EBI-10172511;
CC Q9H2X0; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-947551, EBI-3958099;
CC Q9H2X0; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-947551, EBI-1044640;
CC Q9H2X0; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-947551, EBI-1043191;
CC Q9H2X0; Q5T751: LCE1C; NbExp=3; IntAct=EBI-947551, EBI-12224199;
CC Q9H2X0; Q5T754: LCE1F; NbExp=3; IntAct=EBI-947551, EBI-11958008;
CC Q9H2X0; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-947551, EBI-11955689;
CC Q9H2X0; O14910: LIN7A; NbExp=3; IntAct=EBI-947551, EBI-2513988;
CC Q9H2X0; P50222: MEOX2; NbExp=3; IntAct=EBI-947551, EBI-748397;
CC Q9H2X0; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-947551, EBI-16439278;
CC Q9H2X0; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-947551, EBI-945833;
CC Q9H2X0; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-947551, EBI-22310682;
CC Q9H2X0; Q92570: NR4A3; NbExp=3; IntAct=EBI-947551, EBI-13644623;
CC Q9H2X0; P32242: OTX1; NbExp=3; IntAct=EBI-947551, EBI-740446;
CC Q9H2X0; O15162: PLSCR1; NbExp=3; IntAct=EBI-947551, EBI-740019;
CC Q9H2X0; Q12837: POU4F2; NbExp=3; IntAct=EBI-947551, EBI-17236143;
CC Q9H2X0; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-947551, EBI-3918154;
CC Q9H2X0; Q16348: SLC15A2; NbExp=3; IntAct=EBI-947551, EBI-12806032;
CC Q9H2X0; P84022: SMAD3; NbExp=2; IntAct=EBI-947551, EBI-347161;
CC Q9H2X0; O43609: SPRY1; NbExp=3; IntAct=EBI-947551, EBI-3866665;
CC Q9H2X0; O43597: SPRY2; NbExp=3; IntAct=EBI-947551, EBI-742487;
CC Q9H2X0; O43610: SPRY3; NbExp=3; IntAct=EBI-947551, EBI-12290641;
CC Q9H2X0; Q8IWZ5: TRIM42; NbExp=5; IntAct=EBI-947551, EBI-5235829;
CC Q9H2X0; O14817: TSPAN4; NbExp=3; IntAct=EBI-947551, EBI-8652667;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Comment=Experimental confirmation may be lacking for some isoforms.;
CC Name=1;
CC IsoId=Q9H2X0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H2X0-2; Sequence=VSP_001069, VSP_001070;
CC Name=3;
CC IsoId=Q9H2X0-3; Sequence=VSP_001071, VSP_001072;
CC Name=4;
CC IsoId=Q9H2X0-4; Sequence=VSP_001073, VSP_001074;
CC Name=5;
CC IsoId=Q9H2X0-5; Sequence=VSP_001075;
CC -!- TISSUE SPECIFICITY: Expressed at the highest level in liver.
CC -!- PTM: Cleaved by tolloid proteases; cleavage participates in
CC dorsoventral patterning during early development. {ECO:0000250}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the chordin family. {ECO:0000305}.
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DR EMBL; AF209928; AAG35767.1; -; mRNA.
DR EMBL; AF209929; AAG35768.1; -; mRNA.
DR EMBL; AF209930; AAG35769.1; -; mRNA.
DR EMBL; AF283325; AAG35784.1; -; mRNA.
DR EMBL; AY358926; AAQ89285.1; -; mRNA.
DR EMBL; BC112345; AAI12346.1; -; mRNA.
DR EMBL; AF076612; AAC69835.1; -; mRNA.
DR EMBL; AF136632; AAF70236.1; -; Genomic_DNA.
DR EMBL; AF136633; AAF70237.1; -; Genomic_DNA.
DR EMBL; AF136634; AAF70238.1; -; Genomic_DNA.
DR EMBL; AF136635; AAF70239.1; -; Genomic_DNA.
DR CCDS; CCDS3266.1; -. [Q9H2X0-1]
DR RefSeq; NP_001291401.1; NM_001304472.1.
DR RefSeq; NP_001291402.1; NM_001304473.1.
DR RefSeq; NP_001291403.1; NM_001304474.1.
DR RefSeq; NP_003732.2; NM_003741.3. [Q9H2X0-1]
DR AlphaFoldDB; Q9H2X0; -.
DR SMR; Q9H2X0; -.
DR BioGRID; 114198; 122.
DR DIP; DIP-48857N; -.
DR IntAct; Q9H2X0; 57.
DR MINT; Q9H2X0; -.
DR STRING; 9606.ENSP00000204604; -.
DR GlyGen; Q9H2X0; 4 sites.
DR iPTMnet; Q9H2X0; -.
DR PhosphoSitePlus; Q9H2X0; -.
DR BioMuta; CHRD; -.
DR DMDM; 118572631; -.
DR jPOST; Q9H2X0; -.
DR MassIVE; Q9H2X0; -.
DR PaxDb; Q9H2X0; -.
DR PeptideAtlas; Q9H2X0; -.
DR PRIDE; Q9H2X0; -.
DR ProteomicsDB; 80611; -. [Q9H2X0-1]
DR ProteomicsDB; 80612; -. [Q9H2X0-2]
DR ProteomicsDB; 80613; -. [Q9H2X0-3]
DR ProteomicsDB; 80614; -. [Q9H2X0-4]
DR ProteomicsDB; 80615; -. [Q9H2X0-5]
DR Antibodypedia; 33823; 258 antibodies from 27 providers.
DR DNASU; 8646; -.
DR Ensembl; ENST00000204604.5; ENSP00000204604.1; ENSG00000090539.15. [Q9H2X0-1]
DR Ensembl; ENST00000348986.3; ENSP00000334036.4; ENSG00000090539.15. [Q9H2X0-5]
DR Ensembl; ENST00000356534.7; ENSP00000348930.3; ENSG00000090539.15. [Q9H2X0-2]
DR Ensembl; ENST00000420973.5; ENSP00000392794.1; ENSG00000090539.15. [Q9H2X0-4]
DR Ensembl; ENST00000448472.5; ENSP00000408624.1; ENSG00000090539.15. [Q9H2X0-3]
DR GeneID; 8646; -.
DR KEGG; hsa:8646; -.
DR MANE-Select; ENST00000204604.6; ENSP00000204604.1; NM_003741.4; NP_003732.2.
DR UCSC; uc003fov.3; human. [Q9H2X0-1]
DR CTD; 8646; -.
DR DisGeNET; 8646; -.
DR GeneCards; CHRD; -.
DR HGNC; HGNC:1949; CHRD.
DR HPA; ENSG00000090539; Tissue enhanced (liver).
DR MIM; 603475; gene.
DR neXtProt; NX_Q9H2X0; -.
DR OpenTargets; ENSG00000090539; -.
DR PharmGKB; PA26482; -.
DR VEuPathDB; HostDB:ENSG00000090539; -.
DR eggNOG; ENOG502QR4J; Eukaryota.
DR GeneTree; ENSGT00940000161767; -.
DR HOGENOM; CLU_2497257_0_0_1; -.
DR InParanoid; Q9H2X0; -.
DR OMA; CCKSCPG; -.
DR OrthoDB; 647180at2759; -.
DR PhylomeDB; Q9H2X0; -.
DR TreeFam; TF106451; -.
DR PathwayCommons; Q9H2X0; -.
DR SignaLink; Q9H2X0; -.
DR BioGRID-ORCS; 8646; 16 hits in 1068 CRISPR screens.
DR GenomeRNAi; 8646; -.
DR Pharos; Q9H2X0; Tbio.
DR PRO; PR:Q9H2X0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9H2X0; protein.
DR Bgee; ENSG00000090539; Expressed in right lobe of liver and 116 other tissues.
DR ExpressionAtlas; Q9H2X0; baseline and differential.
DR Genevisible; Q9H2X0; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0036122; F:BMP binding; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; NAS:BHF-UCL.
DR GO; GO:0021919; P:BMP signaling pathway involved in spinal cord dorsal/ventral patterning; IMP:BHF-UCL.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IBA:GO_Central.
DR GO; GO:0033504; P:floor plate development; TAS:BHF-UCL.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IMP:BHF-UCL.
DR GO; GO:0030336; P:negative regulation of cell migration; IDA:BHF-UCL.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IMP:BHF-UCL.
DR GO; GO:0045785; P:positive regulation of cell adhesion; IDA:BHF-UCL.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:BHF-UCL.
DR GO; GO:0001501; P:skeletal system development; TAS:UniProtKB.
DR InterPro; IPR016353; Chordin.
DR InterPro; IPR010895; CHRD.
DR InterPro; IPR001007; VWF_dom.
DR Pfam; PF07452; CHRD; 2.
DR Pfam; PF00093; VWC; 3.
DR PIRSF; PIRSF002496; Chordin; 1.
DR SMART; SM00754; CHRD; 4.
DR SMART; SM00214; VWC; 4.
DR PROSITE; PS50933; CHRD; 4.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Glycoprotein;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..955
FT /note="Chordin"
FT /id="PRO_0000005364"
FT DOMAIN 49..126
FT /note="VWFC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 168..277
FT /note="CHRD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00230"
FT DOMAIN 279..402
FT /note="CHRD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00230"
FT DOMAIN 403..524
FT /note="CHRD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00230"
FT DOMAIN 530..650
FT /note="CHRD 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00230"
FT DOMAIN 703..763
FT /note="VWFC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 784..850
FT /note="VWFC 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 872..932
FT /note="VWFC 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT REGION 124..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..697
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 217
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 365
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 434
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 85..94
FT /note="PQWGRRTRGP -> TGTLRPREMK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11472837"
FT /id="VSP_001071"
FT VAR_SEQ 85..86
FT /note="PQ -> GP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11472837"
FT /id="VSP_001069"
FT VAR_SEQ 87..955
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11472837"
FT /id="VSP_001070"
FT VAR_SEQ 95..955
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11472837"
FT /id="VSP_001072"
FT VAR_SEQ 328..350
FT /note="GLTQVPLRLQILHQGQLLRELQA -> DSTPGAATARTSGQCLSPGTRLC
FT (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11472837"
FT /id="VSP_001073"
FT VAR_SEQ 351..955
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11472837"
FT /id="VSP_001074"
FT VAR_SEQ 441..480
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:9782094"
FT /id="VSP_001075"
FT VARIANT 94
FT /note="P -> S (in dbSNP:rs34095724)"
FT /id="VAR_048727"
FT VARIANT 630
FT /note="M -> L (in dbSNP:rs16858780)"
FT /evidence="ECO:0000269|PubMed:11472837,
FT ECO:0000269|PubMed:9782094"
FT /id="VAR_021517"
FT CONFLICT 70
FT /note="E -> Q (in Ref. 2; AAQ89285)"
FT /evidence="ECO:0000305"
FT CONFLICT 115..118
FT /note="RQLP -> QVAA (in Ref. 4; AAC69835)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="V -> A (in Ref. 4; AAC69835)"
FT /evidence="ECO:0000305"
FT CONFLICT 216
FT /note="S -> P (in Ref. 4; AAC69835)"
FT /evidence="ECO:0000305"
FT CONFLICT 674
FT /note="T -> P (in Ref. 4; AAC69835)"
FT /evidence="ECO:0000305"
FT CONFLICT 939
FT /note="Missing (in Ref. 2; AAQ89285)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 955 AA; 102032 MW; 53F9D9F39A517686 CRC64;
MPSLPAPPAP LLLLGLLLLG SRPARGAGPE PPVLPIRSEK EPLPVRGAAG CTFGGKVYAL
DETWHPDLGE PFGVMRCVLC ACEAPQWGRR TRGPGRVSCK NIKPECPTPA CGQPRQLPGH
CCQTCPQERS SSERQPSGLS FEYPRDPEHR SYSDRGEPGA EERARGDGHT DFVALLTGPR
SQAVARARVS LLRSSLRFSI SYRRLDRPTR IRFSDSNGSV LFEHPAAPTQ DGLVCGVWRA
VPRLSLRLLR AEQLHVALVT LTHPSGEVWG PLIRHRALAA ETFSAILTLE GPPQQGVGGI
TLLTLSDTED SLHFLLLFRG LLEPRSGGLT QVPLRLQILH QGQLLRELQA NVSAQEPGFA
EVLPNLTVQE MDWLVLGELQ MALEWAGRPG LRISGHIAAR KSCDVLQSVL CGADALIPVQ
TGAAGSASLT LLGNGSLIYQ VQVVGTSSEV VAMTLETKPQ RRDQRTVLCH MAGLQPGGHT
AVGICPGLGA RGAHMLLQNE LFLNVGTKDF PDGELRGHVA ALPYCGHSAR HDTLPVPLAG
ALVLPPVKSQ AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TVTAHLLGPP GTPGPRRLLK
GFYGSEAQGV VKDLEPELLR HLAKGMASLM ITTKGSPRGE LRGQVHIANQ CEVGGLRLEA
AGAEGVRALG APDTASAAPP VVPGLPALAP AKPGGPGRPR DPNTCFFEGQ QRPHGARWAP
NYDPLCSLCT CQRRTVICDP VVCPPPSCPH PVQAPDQCCP VCPEKQDVRD LPGLPRSRDP
GEGCYFDGDR SWRAAGTRWH PVVPPFGLIK CAVCTCKGGT GEVHCEKVQC PRLACAQPVR
VNPTDCCKQC PVGSGAHPQL GDPMQADGPR GCRFAGQWFP ESQSWHPSVP PFGEMSCITC
RCGAGVPHCE RDDCSLPLSC GSGKESRCCS RCTAHRRPAP ETRTDPELEK EAEGS
