CHS1_SOLLC
ID CHS1_SOLLC Reviewed; 389 AA.
AC P23418;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Chalcone synthase 1;
DE EC=2.3.1.74;
DE AltName: Full=Naringenin-chalcone synthase 1;
GN Name=CHS1;
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cotyledon, Hypocotyl, and Leaf;
RX PubMed=1980524; DOI=10.1007/bf00271562;
RA O'Neill S.D., Tong Y., Spoerlein B., Forkmann G., Yoder J.I.;
RT "Molecular genetic analysis of chalcone synthase in Lycopersicon esculentum
RT and an anthocyanin-deficient mutant.";
RL Mol. Gen. Genet. 224:279-288(1990).
CC -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC which can under specific conditions spontaneously isomerize into
CC naringenin.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000305}.
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DR EMBL; X55194; CAA38980.1; -; mRNA.
DR PIR; S12223; S12223.
DR AlphaFoldDB; P23418; -.
DR SMR; P23418; -.
DR STRING; 4081.Solyc09g091510.2.1; -.
DR PaxDb; P23418; -.
DR PRIDE; P23418; -.
DR eggNOG; ENOG502QRSY; Eukaryota.
DR InParanoid; P23418; -.
DR UniPathway; UPA00154; -.
DR Proteomes; UP000004994; Unplaced.
DR ExpressionAtlas; P23418; baseline and differential.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030639; P:polyketide biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; PTHR11877; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; SSF53901; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase; Flavonoid biosynthesis; Reference proteome; Transferase.
FT CHAIN 1..389
FT /note="Chalcone synthase 1"
FT /id="PRO_0000216001"
FT ACT_SITE 164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ SEQUENCE 389 AA; 42552 MW; 553DC69E5EA96A8B CRC64;
MVTVEEYRKA QRAEGPATIL AIGTSTPSNC VDQSTYPDYY FRITNSEHKT ELKEKFKRMC
DKSMIKKRYM HLTEEILKEN PNMCAYMAPS LDARQDIVVV EVPKLGKRGT QKAIKEWGQP
KSKITHLVFC TTSGVDMPAC DYQLAKLLPV RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN
NKGARVLVVC SEITAVTFRG PSESHLDSLV GQALFGDGAA AIIIGSDPII GVERPLFELV
SAAQTLVPDS EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLLEAFQPL GISDWNSLFW
IAHPGGPAIL DQVELKLGLK PEKLRATREV LSNYGNMSSA CVLFILDEMR KASTKEGLGT
TGEGLEWGVL FGFGPGLTVE TVVLHSVAA
