CHS2_SOLLC
ID CHS2_SOLLC Reviewed; 389 AA.
AC P23419;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Chalcone synthase 2;
DE EC=2.3.1.74;
DE AltName: Full=Naringenin-chalcone synthase 2;
GN Name=CHS2;
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cotyledon, Hypocotyl, and Leaf;
RX PubMed=1980524; DOI=10.1007/bf00271562;
RA O'Neill S.D., Tong Y., Spoerlein B., Forkmann G., Yoder J.I.;
RT "Molecular genetic analysis of chalcone synthase in Lycopersicon esculentum
RT and an anthocyanin-deficient mutant.";
RL Mol. Gen. Genet. 224:279-288(1990).
CC -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC which can under specific conditions spontaneously isomerize into
CC naringenin.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000305}.
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DR EMBL; X55195; CAA38981.1; -; mRNA.
DR PIR; S12224; S12224.
DR AlphaFoldDB; P23419; -.
DR SMR; P23419; -.
DR STRING; 4081.Solyc05g053550.2.1; -.
DR PaxDb; P23419; -.
DR PRIDE; P23419; -.
DR eggNOG; ENOG502QRSY; Eukaryota.
DR InParanoid; P23419; -.
DR UniPathway; UPA00154; -.
DR Proteomes; UP000004994; Unplaced.
DR ExpressionAtlas; P23419; baseline and differential.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030639; P:polyketide biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; PTHR11877; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; SSF53901; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 2: Evidence at transcript level;
KW Acyltransferase; Flavonoid biosynthesis; Reference proteome; Transferase.
FT CHAIN 1..389
FT /note="Chalcone synthase 2"
FT /id="PRO_0000216002"
FT ACT_SITE 164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ SEQUENCE 389 AA; 42730 MW; F92E46BB3B5FC32F CRC64;
MVTVEEVRRA QRAKGPATIM AIGTATPSNC VDQSTYPDYY FRITNSEHMT ELKEKFKRMC
DKSMINKRYM HLTEEILKEN PNICEYMAPS LDARQDIVVV EVPKLGKEAA QKAIKEWGQP
KSKITHVVFC TTSGVDMPGA DYQLTKLLGL RPSVKRLMMY QQGCFAGGTV IRLAKDLAEN
NKGARVLVVC SEITAVTFRG PSDTHLDSMV GQALFGDRAA AMIIGSDPLP EVERPLFELV
SAAQTLLPDS EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLIEAFQPL GISDWNSIFW
IAHPGGPAIL DQVELKLSLK PEKLRATRQV LSDYGNMSSA CVLFILDEMR KASSKEGLST
TGEGLDWGVL FGFGPGLTVE TVVLHSVST
