CHS3_SOYBN
ID CHS3_SOYBN Reviewed; 388 AA.
AC P19168;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Chalcone synthase 3;
DE EC=2.3.1.74;
DE AltName: Full=Naringenin-chalcone synthase 3;
GN Name=CHS3;
OS Glycine max (Soybean) (Glycine hispida).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3847;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Williams;
RX PubMed=2216793; DOI=10.1093/nar/18.19.5899;
RA Akada S., Kung S.D., Dube S.K.;
RT "The nucleotide sequence of gene 3 of the soybean chalcone synthase
RT multigene family.";
RL Nucleic Acids Res. 18:5899-5899(1990).
CC -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC which can under specific conditions spontaneously isomerize into
CC naringenin.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000305}.
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DR EMBL; X53958; CAA37909.1; -; Genomic_DNA.
DR PIR; S11486; SYSYC3.
DR AlphaFoldDB; P19168; -.
DR SMR; P19168; -.
DR STRING; 3847.GLYMA08G11530.1; -.
DR eggNOG; ENOG502QRSY; Eukaryota.
DR InParanoid; P19168; -.
DR UniPathway; UPA00154; -.
DR Proteomes; UP000008827; Unplaced.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030639; P:polyketide biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; PTHR11877; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; SSF53901; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Flavonoid biosynthesis; Reference proteome; Transferase.
FT CHAIN 1..388
FT /note="Chalcone synthase 3"
FT /id="PRO_0000216064"
FT ACT_SITE 164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ SEQUENCE 388 AA; 42389 MW; 00FFD0982F2B6BB0 CRC64;
MVSVEEIRNA QRAEGPATVM AIGTATPPNC VDQSTYPDYY FRITNSEHMT ELKEKFKRMC
DKSMIKKRYM YLNEEILKEN PSVCAYMAPS LDARQDMVVV EVPKLGKEAA TKAIKEWGQP
KSKITHLIFC TTSGVDMPGA DYQLTKLLGL RPSVKRYMMY QQGCFAGGTV LRLAKDLAEN
NKGARVLVVC SEITAVTFRG PTDTHLDSLV GQALFGDGAA AVIVGSDPLP VEKPLFQLVW
TAQTILPDSE GAIDGHLGEV GLTFHLLKDV PGLISKNIEK ALVEAFQPLG ISDYNSIFWI
AHPGGPAILD QVEAKLGLKP EKMEATRHVL SEYGNMSSAC VLFILDQMRK KSIENGLGTT
GEGLDWGVLF GFGPGLTVET VVLRSVTV
