CHS7_ASHGO
ID CHS7_ASHGO Reviewed; 339 AA.
AC Q754N9; Q9P8V1;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Chitin synthase export chaperone;
GN Name=CHS7; OrderedLocusNames=AFR033C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 225-339.
RX PubMed=10721732; DOI=10.1016/s0378-1119(99)00509-0;
RA Wendland J., Ayad-Durieux Y., Knechtle P., Rebischung C., Philippsen P.;
RT "PCR-based gene targeting in the filamentous fungus Ashbya gossypii.";
RL Gene 242:381-391(2000).
CC -!- FUNCTION: Chaperone required for the export of the chitin synthase CHS3
CC from the endoplasmic reticulum. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CHS3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CHS7 family. {ECO:0000305}.
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DR EMBL; AE016819; AAS53404.1; -; Genomic_DNA.
DR EMBL; AF195003; AAF34904.1; -; Genomic_DNA.
DR RefSeq; NP_985580.1; NM_210934.1.
DR AlphaFoldDB; Q754N9; -.
DR STRING; 33169.AAS53404; -.
DR EnsemblFungi; AAS53404; AAS53404; AGOS_AFR033C.
DR GeneID; 4621820; -.
DR KEGG; ago:AGOS_AFR033C; -.
DR eggNOG; ENOG502QRVH; Eukaryota.
DR HOGENOM; CLU_050424_0_1_1; -.
DR InParanoid; Q754N9; -.
DR OMA; SKATVWE; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0005935; C:cellular bud neck; IEA:EnsemblFungi.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:EnsemblFungi.
DR GO; GO:0034221; P:fungal-type cell wall chitin biosynthetic process; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR022057; Chs7.
DR PANTHER; PTHR35329; PTHR35329; 1.
DR Pfam; PF12271; Chs7; 1.
PE 3: Inferred from homology;
KW Cell wall biogenesis/degradation; Endoplasmic reticulum; Membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..339
FT /note="Chitin synthase export chaperone"
FT /id="PRO_0000280567"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 237
FT /note="L -> F (in Ref. 3; AAF34904)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 339 AA; 37333 MW; 246992759DC44454 CRC64;
MSSKEAPMRA WLKMAGLAMS NKSWLSLGDF AGICAKTPLP MCFVVQTSSL PGGSVGATHY
DRTHMNIGMV PRCYSRTVDI ANTAIFQLGN AFVNILALCV ILIISYNIRF KYTAIGRSEY
GYFFQLCFML ICMTLVVDCG VSPPGTLAYP YLAALQIGLA GACSWALAVM GFLGFRLWED
GTRKSMLIVR GVSMVGFLLG SLVSAITFTN WIQHHPDMKT NTTALFVVMY GLNGLALLMY
SVCQLVVSIF VLSNFWMTGS TILGVIFITT GQVLMYTISY EICEGVKHYL DGLFIGSICN
VFALMMIYKT WDISTDEDLE FSVSISVDGD IMYNSNLKL
