ID   CHS7_COCIM              Reviewed;         331 AA.
AC   Q1DKX4; J3K236;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Chitin synthase export chaperone;
GN   Name=CHS7; ORFNames=CIMG_09039;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Chaperone required for the export of the chitin synthase CHS3
CC       from the endoplasmic reticulum. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CHS3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHS7 family. {ECO:0000305}.
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DR   EMBL; GG704915; EAS27835.3; -; Genomic_DNA.
DR   RefSeq; XP_001239418.1; XM_001239417.2.
DR   AlphaFoldDB; Q1DKX4; -.
DR   STRING; 246410.Q1DKX4; -.
DR   EnsemblFungi; EAS27835; EAS27835; CIMG_09039.
DR   GeneID; 4558321; -.
DR   KEGG; cim:CIMG_09039; -.
DR   VEuPathDB; FungiDB:CIMG_09039; -.
DR   InParanoid; Q1DKX4; -.
DR   OMA; SKATVWE; -.
DR   OrthoDB; 1163040at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR022057; Chs7.
DR   PANTHER; PTHR35329; PTHR35329; 1.
DR   Pfam; PF12271; Chs7; 1.
PE   3: Inferred from homology;
KW   Cell wall biogenesis/degradation; Endoplasmic reticulum; Membrane;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..331
FT                   /note="Chitin synthase export chaperone"
FT                   /id="PRO_0000280574"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   331 AA;  36683 MW;  F8D0823DD5FA2D18 CRC64;
     MSFGQFDSLC RKAAIPLCSL VGSSSLSGTK GILPSCYARN IEVANTIIFQ GATDVMHIVA
     LAMTAIMIIH VRSKFTAVGR KEIITFFYIY MALTICSLVL DSGVAPPGNA VFPFFAAVQN
     GFASALCTCL LVNGFVGFQL YEDGTALSVW LLRLSSLGMF LISGAVSLLT FKSWAGLSPS
     NTIGLFVVVY ILNAICLFVY VVMQIILVVN TLQDRWPLWH ITFGVFFFII GQVILYSFSA
     VICESVQHYL DGLFFATLCN LLAVMMIYKY WDSITKEDLE FSVGLKQNNW EVKELLPEEE
     RRATVYLDTN SEYAGSVYHH RSSTYGGQSN Y