ID   CHS7_CRYNB              Reviewed;         361 AA.
AC   P0CM73; Q55JM1; Q5K9Y1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Chitin synthase export chaperone;
GN   Name=CHS7; OrderedLocusNames=CNBK3120;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Chaperone required for the export of the chitin synthase CHS3
CC       from the endoplasmic reticulum. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CHS3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHS7 family. {ECO:0000305}.
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DR   EMBL; AAEY01000053; EAL17961.1; -; Genomic_DNA.
DR   RefSeq; XP_772608.1; XM_767515.1.
DR   AlphaFoldDB; P0CM73; -.
DR   EnsemblFungi; EAL17961; EAL17961; CNBK3120.
DR   GeneID; 4939013; -.
DR   KEGG; cnb:CNBK3120; -.
DR   VEuPathDB; FungiDB:CNBK3120; -.
DR   HOGENOM; CLU_050424_1_0_1; -.
DR   Proteomes; UP000001435; Chromosome 11.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR022057; Chs7.
DR   PANTHER; PTHR35329; PTHR35329; 1.
DR   Pfam; PF12271; Chs7; 1.
PE   3: Inferred from homology;
KW   Cell wall biogenesis/degradation; Endoplasmic reticulum; Membrane;
KW   Protein transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..361
FT                   /note="Chitin synthase export chaperone"
FT                   /id="PRO_0000410039"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   361 AA;  39815 MW;  A32C86D1A47E9212 CRC64;
     MSDNAAFKFG SFDYICEHAA LVVCPMLGDQ QGMAPTCYSR NVQLGSQIIF QPATCILHIA
     ALVMATIMLL HVRSKYTAVG RKEIVLFFYM YIWVELFAIF LDSAIIPTAN KVYPWFAAIY
     AGSVGALYWC LLLNGFVGFQ FHEDGTPMSL WFLRISSLVV GAVCFGIPVA TFKGTSSSMS
     PTNTVGLFIT YLVFPCVCVL IYFISQMLLV VRTLDDRWVI GDLVFMAGFY IAGVLLLVTF
     SVTICDAVKH YVDGVFFSTL AFLFAVMMVY KYWDSITKED LEFSVGSKQA VWDVKDPLLA
     TGMEYYEDDA QSAYRGAGGS LVGGYNGNQY YGNQPGYAQS AYGQQGYGQY GAGGGYGQGH
     Y