ID   CHS7_CRYNJ              Reviewed;         361 AA.
AC   P0CM72; Q55JM1; Q5K9Y1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Chitin synthase export chaperone;
GN   Name=CHS7; OrderedLocusNames=CNK00300;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Chaperone required for the export of the chitin synthase CHS3
CC       from the endoplasmic reticulum. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CHS3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHS7 family. {ECO:0000305}.
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DR   EMBL; AE017351; AAW46083.1; -; Genomic_DNA.
DR   RefSeq; XP_567600.1; XM_567600.1.
DR   AlphaFoldDB; P0CM72; -.
DR   STRING; 5207.AAW46083; -.
DR   PaxDb; P0CM72; -.
DR   EnsemblFungi; AAW46083; AAW46083; CNK00300.
DR   GeneID; 3254493; -.
DR   KEGG; cne:CNK00300; -.
DR   VEuPathDB; FungiDB:CNK00300; -.
DR   eggNOG; ENOG502QRVH; Eukaryota.
DR   HOGENOM; CLU_050424_1_0_1; -.
DR   InParanoid; P0CM72; -.
DR   OMA; NICESMS; -.
DR   OrthoDB; 1163040at2759; -.
DR   Proteomes; UP000002149; Chromosome 11.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0034221; P:fungal-type cell wall chitin biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR022057; Chs7.
DR   PANTHER; PTHR35329; PTHR35329; 1.
DR   Pfam; PF12271; Chs7; 1.
PE   3: Inferred from homology;
KW   Cell wall biogenesis/degradation; Endoplasmic reticulum; Membrane;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..361
FT                   /note="Chitin synthase export chaperone"
FT                   /id="PRO_0000280575"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   361 AA;  39829 MW;  3940AEAD567E920E CRC64;
     MSDNAAFKFG SFDYICEHAA LVVCPMLGDQ QGMAPTCYSR NVQLGSQIIF QPATCILHIA
     ALVMATIMLL HVRSKYTAVG RKEIVLFFYM YIWVELFAIF LDSAIIPTAN KVYPWFAAIY
     AGSVGALYWC LLLNGFVGFQ FHEDGTPMSL WFLRISSLVV GAVCFGIPVA TFKGTSSSMS
     PTNTVGLFIT YLVFPCVCVL IYFISQMLLV VRTLDDRWVI GDLLFMAGFY IAGVLLLVTF
     SVTICDAVKH YVDGVFFSTL AFLFAVMMVY KYWDSITKED LEFSVGSKQA VWDVKDPLLA
     TGMEYYEDDA QSAYRGAGGS LVGGYNGNQY YGNQPGYAQS AYGQQGYGQY GAGGGYGQGH
     Y