ID   CHS7_NEUCR              Reviewed;         358 AA.
AC   Q7SB92;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Chitin synthase export chaperone;
DE   AltName: Full=Chitin synthase chaperone 1;
GN   Name=csc-1; Synonyms=chs7; ORFNames=NCU05720;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Chaperone required for the export of the chitin synthase chs-
CC       3 from the endoplasmic reticulum. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with chs-3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHS7 family. {ECO:0000305}.
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DR   EMBL; CM002238; EAA33670.3; -; Genomic_DNA.
DR   RefSeq; XP_962906.3; XM_957813.3.
DR   AlphaFoldDB; Q7SB92; -.
DR   STRING; 5141.EFNCRP00000007629; -.
DR   EnsemblFungi; EAA33670; EAA33670; NCU05720.
DR   GeneID; 3879045; -.
DR   KEGG; ncr:NCU05720; -.
DR   VEuPathDB; FungiDB:NCU05720; -.
DR   HOGENOM; CLU_050424_1_1_1; -.
DR   InParanoid; Q7SB92; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0034221; P:fungal-type cell wall chitin biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR022057; Chs7.
DR   PANTHER; PTHR35329; PTHR35329; 1.
DR   Pfam; PF12271; Chs7; 1.
PE   3: Inferred from homology;
KW   Cell wall biogenesis/degradation; Endoplasmic reticulum; Membrane;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..358
FT                   /note="Chitin synthase export chaperone"
FT                   /id="PRO_0000280581"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          321..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   358 AA;  39306 MW;  1BD369FA13CE5058 CRC64;
     MGKFGDFSSI CRMAPIPLCA SVGPITSIAT GVGIEPDCYA RNIEVANTII FQGAASVMHI
     VALVMTVVML LHVRGKFTAV GRKEITTFFY LYMILTFLSL CIDAGVIPPH SGSYPYFVAV
     QAGLASALVT CLVINGFVGF QLYEDGTPLS LWMLRLCSFV AFVISFLVGL ATFKSWAGLG
     PTNTVGIFVV LYFLNALQLL LYVVMQIILV TRTLQDRWPL GDIAFGLFFF IAGQVILYAF
     SSPICEGISH YLDGLFFATT CNLLAVMMVY KYWDSITKED LEFSVGTRMN NWEVKELLPQ
     GPEEDRRATV YADPIYEGHY ASGPGTGSGA SASGYEGGHH RRESHGYTPS PNRQSLRY